Abstract
Matrix metalloproteinases (MMPs) play important roles in solid tumor invasion and migration. In this study, we showed that 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) dose-dependently inhibited HT1080 cell invasion and migration, and decreased MMP-2 and MMP-9 activities. Furthermore, FPP-3 reduced MMP-2 expression at protein and mRNA levels, and suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced expression of MT1-MMP without changing tissue inhibitors of metalloproteinase (TIMP)-2 level. FPP-3 also suppressed TPA-induced increases in MMP-9 protein and mRNA levels, but did not alter TIMP-1 level. Our results suggest that FFP-3 may be a valuable anti-invasive drug candidate for cancer therapy by suppressing MMP-2, MMP-9, and MT1-MMP.
Original language | English |
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Pages (from-to) | 193-197 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 567 |
Issue number | 3 |
DOIs | |
State | Published - 19 Jul 2007 |
Bibliographical note
Funding Information:This work was supported by a grant No. RTI04-01-04 from the Regional Technology Innovation Program of the Ministry of Commerce, Industry, and Energy (MOCIE).
Keywords
- 1-furan-2-yl-3-pyridin-2-yl-propenone
- MMP-2
- MMP-9
- MT1-MMP
- TIMP