A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle

Kyoung Sub Kim; Wooram Park; Jun Hu; You Han Bae; Kun Na

doi:10.1016/j.biomaterials.2013.10.004

A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle

Kyoung Sub Kim
, Wooram Park
, Jun Hu
, You Han Bae
, Kun Na

Research output: Contribution to journal › Article › peer-review

170 Scopus citations

Abstract

A cancer-recognizable MRI contrast agents (CR-CAs) has been developed using pH-responsive polymeric micelles. The CR-CAs with pH sensitivity were self-assembled based on well-defined amphiphilic block copolymers, consisting of methoxy poly(ethylene glycol)-b-poly(l-histidine) (PEG-p(l-His)) and methoxy poly(ethylene glycol)-b-poly(l-lactic acid)-diethylenetriaminopentaacetic acid dianhydride-gadolinium chelate (PEG-p(l-LA)-DTPA-Gd). The CR-CAs have a spherical shape with a uniform size of ~40nm at physiological pH (pH 7.4). However, in acidic tumoral environment (pH 6.5), the CR-CAs were destabilized due to the protonation of the imidazole groups of p(l-His) blocks, causing them to break apart into positively charged water-soluble polymers. As a result, the CR-CAs exhibit highly effective T₁ MR contrast enhancement in the tumor region, which enabled the detection of small tumors of ~3mm³ invivo at 1.5T within a few minutes.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	Biomaterials
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.biomaterials.2013.10.004
State	Published - 2014

Bibliographical note

Funding Information:
We acknowledge the financial support of the Korean Ministry of Education, Science and Technology through Strategic Research ( 2011-0028726 ).

Keywords

Cancer diagnosis
Imaging agents
Magnetic resonance imaging
Micelles
PH-responsive materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2013.10.004

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title = "A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle",

abstract = "A cancer-recognizable MRI contrast agents (CR-CAs) has been developed using pH-responsive polymeric micelles. The CR-CAs with pH sensitivity were self-assembled based on well-defined amphiphilic block copolymers, consisting of methoxy poly(ethylene glycol)-b-poly(l-histidine) (PEG-p(l-His)) and methoxy poly(ethylene glycol)-b-poly(l-lactic acid)-diethylenetriaminopentaacetic acid dianhydride-gadolinium chelate (PEG-p(l-LA)-DTPA-Gd). The CR-CAs have a spherical shape with a uniform size of \textasciitilde{}40nm at physiological pH (pH 7.4). However, in acidic tumoral environment (pH 6.5), the CR-CAs were destabilized due to the protonation of the imidazole groups of p(l-His) blocks, causing them to break apart into positively charged water-soluble polymers. As a result, the CR-CAs exhibit highly effective T1 MR contrast enhancement in the tumor region, which enabled the detection of small tumors of \textasciitilde{}3mm3 invivo at 1.5T within a few minutes.",

keywords = "Cancer diagnosis, Imaging agents, Magnetic resonance imaging, Micelles, PH-responsive materials",

author = "Kim, \{Kyoung Sub\} and Wooram Park and Jun Hu and Bae, \{You Han\} and Kun Na",

note = "Funding Information: We acknowledge the financial support of the Korean Ministry of Education, Science and Technology through Strategic Research ( 2011-0028726 ). ",

year = "2014",

doi = "10.1016/j.biomaterials.2013.10.004",

language = "English",

volume = "35",

pages = "337--343",

journal = "Biomaterials",

issn = "0142-9612",

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T1 - A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle

AU - Kim, Kyoung Sub

AU - Park, Wooram

AU - Hu, Jun

AU - Bae, You Han

AU - Na, Kun

N1 - Funding Information: We acknowledge the financial support of the Korean Ministry of Education, Science and Technology through Strategic Research ( 2011-0028726 ).

PY - 2014

Y1 - 2014

N2 - A cancer-recognizable MRI contrast agents (CR-CAs) has been developed using pH-responsive polymeric micelles. The CR-CAs with pH sensitivity were self-assembled based on well-defined amphiphilic block copolymers, consisting of methoxy poly(ethylene glycol)-b-poly(l-histidine) (PEG-p(l-His)) and methoxy poly(ethylene glycol)-b-poly(l-lactic acid)-diethylenetriaminopentaacetic acid dianhydride-gadolinium chelate (PEG-p(l-LA)-DTPA-Gd). The CR-CAs have a spherical shape with a uniform size of ~40nm at physiological pH (pH 7.4). However, in acidic tumoral environment (pH 6.5), the CR-CAs were destabilized due to the protonation of the imidazole groups of p(l-His) blocks, causing them to break apart into positively charged water-soluble polymers. As a result, the CR-CAs exhibit highly effective T1 MR contrast enhancement in the tumor region, which enabled the detection of small tumors of ~3mm3 invivo at 1.5T within a few minutes.

AB - A cancer-recognizable MRI contrast agents (CR-CAs) has been developed using pH-responsive polymeric micelles. The CR-CAs with pH sensitivity were self-assembled based on well-defined amphiphilic block copolymers, consisting of methoxy poly(ethylene glycol)-b-poly(l-histidine) (PEG-p(l-His)) and methoxy poly(ethylene glycol)-b-poly(l-lactic acid)-diethylenetriaminopentaacetic acid dianhydride-gadolinium chelate (PEG-p(l-LA)-DTPA-Gd). The CR-CAs have a spherical shape with a uniform size of ~40nm at physiological pH (pH 7.4). However, in acidic tumoral environment (pH 6.5), the CR-CAs were destabilized due to the protonation of the imidazole groups of p(l-His) blocks, causing them to break apart into positively charged water-soluble polymers. As a result, the CR-CAs exhibit highly effective T1 MR contrast enhancement in the tumor region, which enabled the detection of small tumors of ~3mm3 invivo at 1.5T within a few minutes.

KW - Cancer diagnosis

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Micelles

KW - PH-responsive materials

UR - https://www.scopus.com/pages/publications/84887014757

U2 - 10.1016/j.biomaterials.2013.10.004

DO - 10.1016/j.biomaterials.2013.10.004

M3 - Article

C2 - 24139764

AN - SCOPUS:84887014757

SN - 0142-9612

VL - 35

SP - 337

EP - 343

JO - Biomaterials

JF - Biomaterials

IS - 1

ER -

A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle

Abstract

Bibliographical note

Keywords

UN SDGs

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