A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession

Lichen amyloidosis (LA) is a chronic, severely pruritic skin disease characterized by deposition of amyloid in the skin with no visceral involvement. Current treatments of LA are unsatisfactory, with high relapse rates, complications, and treatment failures. A 31-year-old woman with a history of refractory atopic dermatitis (AD) presented with pruritic, multiple, discrete papules on the extremities and back. Histopathologic examination confirmed the diagnosis of LA. A treatment regimen of oral cyclosporine and subsequent narrow band UVB (NBUVB) for a total of 8 months resulted in nearly complete regression. Although further studies are required to define the exact mechanism of action of this treatment regimen (oral cyclosporine NBUVB), it seems to be an effective alternative in treating patients with LA and/or AD-associated LA.