A case of concomitant keratoconus and granular corneal dystrophy type II

Chang Rae Rho; Jin Hyung Park; Youn Hea Jung; Man Soo Kim

doi:10.1016/j.clae.2014.02.001

A case of concomitant keratoconus and granular corneal dystrophy type II

Chang Rae Rho, Jin Hyung Park, Youn Hea Jung, Man Soo Kim

Department of Ophthalmology

Catholic Univ. of Korea Coll. Med.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose: We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II. Methods: Case report. Results: A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus. Conclusion: Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.

Original language	English
Pages (from-to)	314-316
Number of pages	3
Journal	Contact Lens and Anterior Eye
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/j.clae.2014.02.001
State	Published - Aug 2014

Keywords

BIGH3
Corneal topography
Granular corneal dystrophy
Keratoconus

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10.1016/j.clae.2014.02.001

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title = "A case of concomitant keratoconus and granular corneal dystrophy type II",

abstract = "Purpose: We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II. Methods: Case report. Results: A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus. Conclusion: Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.",

keywords = "BIGH3, Corneal topography, Granular corneal dystrophy, Keratoconus",

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AU - Rho, Chang Rae

AU - Park, Jin Hyung

AU - Jung, Youn Hea

AU - Kim, Man Soo

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N2 - Purpose: We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II. Methods: Case report. Results: A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus. Conclusion: Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.

AB - Purpose: We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II. Methods: Case report. Results: A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus. Conclusion: Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.

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A case of concomitant keratoconus and granular corneal dystrophy type II

Abstract

Keywords

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