A Case of Marrow Fibrosis with Megakaryocytic Hyperplasia after Short-Term use of Granulocyte Colony-Stimulating Factor

Eunhee Han, Mi Hyun Bae, Dong Hyun Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Administration of granulocyte colony-stimulating factors G-SCFs can cause diagnostic challenges because of morphologic alteration of hematopoietic cells. Methods: We experienced a patient who showed distinctive clinical and morphologic findings after short time use of G-CSF. The clinical information and examination results of the morphology of bone marrow (BM) specimen and karyotype were analyzed by reviewing relevant literature. Results: White blood cell (WBC) counts of the patient were unresponsive to G-CSF and marrow fibrosis and megakaryocytic hyperplasia were accompanied with increase of blasts in BM. Presence of malignant clones was confirmed by cytogenetic aberrations of monosomy 7. Conclusions: We concluded, BM study including cytogenetic analysis should be performed when such clinical findings are encountered and the possibility of hematologic malignancy should be considered.

Original languageEnglish
Pages (from-to)2008-2010
Number of pages3
JournalClinical Laboratory
Volume69
DOIs
StatePublished - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 Verlag Klinisches Labor GmbH. All rights reserved.

Keywords

  • bone marrow fi-brosis
  • granulocyte colony-stimulating factor
  • megakaryocytic hyperplasia
  • monosomy 7

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