Abstract
Background: Administration of granulocyte colony-stimulating factors G-SCFs can cause diagnostic challenges because of morphologic alteration of hematopoietic cells. Methods: We experienced a patient who showed distinctive clinical and morphologic findings after short time use of G-CSF. The clinical information and examination results of the morphology of bone marrow (BM) specimen and karyotype were analyzed by reviewing relevant literature. Results: White blood cell (WBC) counts of the patient were unresponsive to G-CSF and marrow fibrosis and megakaryocytic hyperplasia were accompanied with increase of blasts in BM. Presence of malignant clones was confirmed by cytogenetic aberrations of monosomy 7. Conclusions: We concluded, BM study including cytogenetic analysis should be performed when such clinical findings are encountered and the possibility of hematologic malignancy should be considered.
Original language | English |
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Pages (from-to) | 2008-2010 |
Number of pages | 3 |
Journal | Clinical Laboratory |
Volume | 69 |
DOIs | |
State | Published - Sep 2023 |
Bibliographical note
Publisher Copyright:© 2023 Verlag Klinisches Labor GmbH. All rights reserved.
Keywords
- bone marrow fi-brosis
- granulocyte colony-stimulating factor
- megakaryocytic hyperplasia
- monosomy 7