A case of subcutaneous granuloma pyogenicum of the finger during pregnancy

Subcutaneous granuloma pyogenicum is a rare variant of granuloma pyogenicum. It is often difficult to diagnose based on its clinical features because it appears as a nonspecific deep nodule lacking the characteristic surface changes such as erosion or ulceration, which are the characteristics of common polypoid granuloma pyogenicum. A 28-year- old primigravida presented at 6 months' gestation with a 8-week history of an enlarging mass on the volar aspect of her left thumb. Histological examination revealed that a well-defined tumor nodule occupying the lower dermis and subcutaneous layer was composed of a proliferation of capillaries arranged in a distinct lobular architecture, which is the hallmark of all variants of granuloma pyogenicum. This case suggests additional evidence of the possible role of female sex hormones in the pathogenesis of subcutaneous granuloma pyogenicum.