A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view

Ok R. Shin; Yang R. Kim; Tae hyun Ban; Taeseok Lim; Tae H. Han; Su Yeon Kim; Kyung J. Seo

doi:10.1186/1746-1596-9-62

A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view

Ok R. Shin
, Yang R. Kim
, Tae hyun Ban
, Taeseok Lim
, Tae H. Han
, Su Yeon Kim
, Kyung J. Seo

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease in a 39-yr-old male patient with fever and left axillary lymphadenitis. He had a history of cat bite on the left hand dorsum. On excision, the lymph node showed follicular hyperplasia, stellate microabscesses with a rim of granulomatous inflammation. Warthin-Starry silver staining showed many clumps of silver-stained bacilli within the necrotic foci. Serological tests were negative. Diagnosis was established by PCR analysis.The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1877499238123059.

Original language	English
Article number	62
Journal	Diagnostic Pathology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/1746-1596-9-62
State	Published - 19 Mar 2014

Keywords

Bartonella
Cat scratch disease
Differential diagnosis
Histological features
PCR
Warthin-Starry silver stain

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10.1186/1746-1596-9-62

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title = "A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view",

abstract = "Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease in a 39-yr-old male patient with fever and left axillary lymphadenitis. He had a history of cat bite on the left hand dorsum. On excision, the lymph node showed follicular hyperplasia, stellate microabscesses with a rim of granulomatous inflammation. Warthin-Starry silver staining showed many clumps of silver-stained bacilli within the necrotic foci. Serological tests were negative. Diagnosis was established by PCR analysis.The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1877499238123059.",

keywords = "Bartonella, Cat scratch disease, Differential diagnosis, Histological features, PCR, Warthin-Starry silver stain",

author = "Shin, \{Ok R.\} and Kim, \{Yang R.\} and Ban, \{Tae hyun\} and Taeseok Lim and Han, \{Tae H.\} and Kim, \{Su Yeon\} and Seo, \{Kyung J.\}",

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doi = "10.1186/1746-1596-9-62",

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AU - Shin, Ok R.

AU - Kim, Yang R.

AU - Ban, Tae hyun

AU - Lim, Taeseok

AU - Han, Tae H.

AU - Kim, Su Yeon

AU - Seo, Kyung J.

PY - 2014/3/19

Y1 - 2014/3/19

N2 - Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease in a 39-yr-old male patient with fever and left axillary lymphadenitis. He had a history of cat bite on the left hand dorsum. On excision, the lymph node showed follicular hyperplasia, stellate microabscesses with a rim of granulomatous inflammation. Warthin-Starry silver staining showed many clumps of silver-stained bacilli within the necrotic foci. Serological tests were negative. Diagnosis was established by PCR analysis.The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1877499238123059.

AB - Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease in a 39-yr-old male patient with fever and left axillary lymphadenitis. He had a history of cat bite on the left hand dorsum. On excision, the lymph node showed follicular hyperplasia, stellate microabscesses with a rim of granulomatous inflammation. Warthin-Starry silver staining showed many clumps of silver-stained bacilli within the necrotic foci. Serological tests were negative. Diagnosis was established by PCR analysis.The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1877499238123059.

KW - Bartonella

KW - Cat scratch disease

KW - Differential diagnosis

KW - Histological features

KW - PCR

KW - Warthin-Starry silver stain

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JO - Diagnostic Pathology

JF - Diagnostic Pathology

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ER -

A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view

Abstract

Keywords

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