A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer

Mina Yu; Joo Hwan Lee; Hong Seok Jang; Dong Min Jeon; Jae Suk Cheon; Hyo Chun Lee; Jong Hoon Lee

doi:10.1186/1748-717X-8-181

A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer

Mina Yu
, Joo Hwan Lee
, Hong Seok Jang
, Dong Min Jeon
, Jae Suk Cheon
, Hyo Chun Lee
, Jong Hoon Lee

Department of Radiation Oncology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Purpose: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs). The purpose of this study was to compare the dosimetric parameters between Tomotherapy and three-dimensional conformal radiotherapy (3D-CRT) in rectal cancer patients.Materials and methods: We redesigned three-dimensional conformal plans for 20 rectal cancer patients who had received short-course preoperative radiotherapy with Tomotherapy. The target coverage for 3D-CRT and Tomotherapy was evaluated with the following including the mean dose, V_nGy, D_min, D_max, radiation conformality index (RCI), and radical dose homogeneity index (rDHI).Results: The mean PTV dose for Tomotherapy is significantly higher than that observed for the 3D-CRT (p = 0.043). However, there is no significant difference in the V_23.25Gy, V_26.25Gy, V_27.5Gy, and RCI values between Tomotherapy and 3D-CRT. However, the average rDHI (p < 0.001) value for Tomotherapy was significantly lower than that reported for the 3D-CRT. Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.Conclusions: Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.

Original language	English
Article number	181
Journal	Radiation Oncology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/1748-717X-8-181
State	Published - 16 Jul 2013

Bibliographical note

Funding Information:
The authors wish to acknowledge the financial support of the Catholic Medical Center Research Foundation made in the program year of 2013 (5-2013-B0001-00050). Mina Yu and Joo Hwan Lee were equally contributed to this work.

Keywords

Conformal
Dosimetry
Preoperative radiotherapy
Rectal cancer
Tomotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1748-717X-8-181

Cite this

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title = "A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer",

abstract = "Purpose: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs). The purpose of this study was to compare the dosimetric parameters between Tomotherapy and three-dimensional conformal radiotherapy (3D-CRT) in rectal cancer patients.Materials and methods: We redesigned three-dimensional conformal plans for 20 rectal cancer patients who had received short-course preoperative radiotherapy with Tomotherapy. The target coverage for 3D-CRT and Tomotherapy was evaluated with the following including the mean dose, VnGy, Dmin, Dmax, radiation conformality index (RCI), and radical dose homogeneity index (rDHI).Results: The mean PTV dose for Tomotherapy is significantly higher than that observed for the 3D-CRT (p = 0.043). However, there is no significant difference in the V23.25Gy, V26.25Gy, V27.5Gy, and RCI values between Tomotherapy and 3D-CRT. However, the average rDHI (p < 0.001) value for Tomotherapy was significantly lower than that reported for the 3D-CRT. Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.Conclusions: Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.",

keywords = "Conformal, Dosimetry, Preoperative radiotherapy, Rectal cancer, Tomotherapy",

author = "Mina Yu and Lee, \{Joo Hwan\} and Jang, \{Hong Seok\} and Jeon, \{Dong Min\} and Cheon, \{Jae Suk\} and Lee, \{Hyo Chun\} and Lee, \{Jong Hoon\}",

note = "Funding Information: The authors wish to acknowledge the financial support of the Catholic Medical Center Research Foundation made in the program year of 2013 (5-2013-B0001-00050). Mina Yu and Joo Hwan Lee were equally contributed to this work.",

year = "2013",

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doi = "10.1186/1748-717X-8-181",

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AU - Yu, Mina

AU - Lee, Joo Hwan

AU - Jang, Hong Seok

AU - Jeon, Dong Min

AU - Cheon, Jae Suk

AU - Lee, Hyo Chun

AU - Lee, Jong Hoon

N1 - Funding Information: The authors wish to acknowledge the financial support of the Catholic Medical Center Research Foundation made in the program year of 2013 (5-2013-B0001-00050). Mina Yu and Joo Hwan Lee were equally contributed to this work.

PY - 2013/7/16

Y1 - 2013/7/16

N2 - Purpose: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs). The purpose of this study was to compare the dosimetric parameters between Tomotherapy and three-dimensional conformal radiotherapy (3D-CRT) in rectal cancer patients.Materials and methods: We redesigned three-dimensional conformal plans for 20 rectal cancer patients who had received short-course preoperative radiotherapy with Tomotherapy. The target coverage for 3D-CRT and Tomotherapy was evaluated with the following including the mean dose, VnGy, Dmin, Dmax, radiation conformality index (RCI), and radical dose homogeneity index (rDHI).Results: The mean PTV dose for Tomotherapy is significantly higher than that observed for the 3D-CRT (p = 0.043). However, there is no significant difference in the V23.25Gy, V26.25Gy, V27.5Gy, and RCI values between Tomotherapy and 3D-CRT. However, the average rDHI (p < 0.001) value for Tomotherapy was significantly lower than that reported for the 3D-CRT. Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.Conclusions: Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.

AB - Purpose: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs). The purpose of this study was to compare the dosimetric parameters between Tomotherapy and three-dimensional conformal radiotherapy (3D-CRT) in rectal cancer patients.Materials and methods: We redesigned three-dimensional conformal plans for 20 rectal cancer patients who had received short-course preoperative radiotherapy with Tomotherapy. The target coverage for 3D-CRT and Tomotherapy was evaluated with the following including the mean dose, VnGy, Dmin, Dmax, radiation conformality index (RCI), and radical dose homogeneity index (rDHI).Results: The mean PTV dose for Tomotherapy is significantly higher than that observed for the 3D-CRT (p = 0.043). However, there is no significant difference in the V23.25Gy, V26.25Gy, V27.5Gy, and RCI values between Tomotherapy and 3D-CRT. However, the average rDHI (p < 0.001) value for Tomotherapy was significantly lower than that reported for the 3D-CRT. Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.Conclusions: Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.

KW - Conformal

KW - Dosimetry

KW - Preoperative radiotherapy

KW - Rectal cancer

KW - Tomotherapy

UR - https://www.scopus.com/pages/publications/84880110594

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SN - 1748-717X

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JO - Radiation Oncology

JF - Radiation Oncology

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ER -

A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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