A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release

Heebeom Koo; Geun woo Jin; Hyunseo Kang; Yan Lee; Hye Yeong Nam; Hyung suk Jang; Jong Sang Park

doi:10.1016/j.ijpharm.2009.03.010

A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release

Heebeom Koo
, Geun woo Jin
, Hyunseo Kang
, Yan Lee
, Hye Yeong Nam
, Hyung suk Jang
, Jong Sang Park

Department of Biomedicine & Health Science

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 °C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice.

Original language	English
Pages (from-to)	58-65
Number of pages	8
Journal	International Journal of Pharmaceutics
Volume	374
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2009.03.010
State	Published - 5 Jun 2009

Bibliographical note

Funding Information:
We thank Hye Ran Koh at Seoul National University for calculation of activation energy and Dr. Byeongmoon Jung at Ewha Womans University for rheological data. This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A084285) and the Gene Therapy Project of the Ministry of Science and Technology (M10534030004-08N3403-00410).

Keywords

Biodegradable
DDS
Disulfide
Hydrogel
PEG

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10.1016/j.ijpharm.2009.03.010

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title = "A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release",

abstract = "We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 °C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice.",

keywords = "Biodegradable, DDS, Disulfide, Hydrogel, PEG",

author = "Heebeom Koo and Jin, \{Geun woo\} and Hyunseo Kang and Yan Lee and Nam, \{Hye Yeong\} and Jang, \{Hyung suk\} and Park, \{Jong Sang\}",

note = "Funding Information: We thank Hye Ran Koh at Seoul National University for calculation of activation energy and Dr. Byeongmoon Jung at Ewha Womans University for rheological data. This study was supported by a grant of the Korea Healthcare technology R\&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A084285) and the Gene Therapy Project of the Ministry of Science and Technology (M10534030004-08N3403-00410). ",

year = "2009",

month = jun,

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doi = "10.1016/j.ijpharm.2009.03.010",

language = "English",

volume = "374",

pages = "58--65",

journal = "International Journal of Pharmaceutics",

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T1 - A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release

AU - Koo, Heebeom

AU - Jin, Geun woo

AU - Kang, Hyunseo

AU - Lee, Yan

AU - Nam, Hye Yeong

AU - Jang, Hyung suk

AU - Park, Jong Sang

N1 - Funding Information: We thank Hye Ran Koh at Seoul National University for calculation of activation energy and Dr. Byeongmoon Jung at Ewha Womans University for rheological data. This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A084285) and the Gene Therapy Project of the Ministry of Science and Technology (M10534030004-08N3403-00410).

PY - 2009/6/5

Y1 - 2009/6/5

N2 - We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 °C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice.

AB - We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 °C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice.

KW - Biodegradable

KW - DDS

KW - Disulfide

KW - Hydrogel

KW - PEG

UR - https://www.scopus.com/pages/publications/67349106431

U2 - 10.1016/j.ijpharm.2009.03.010

DO - 10.1016/j.ijpharm.2009.03.010

M3 - Article

C2 - 19446760

AN - SCOPUS:67349106431

SN - 0378-5173

VL - 374

SP - 58

EP - 65

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release

Abstract

Bibliographical note

Keywords

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