A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery

Bo Reum Lee; Kyung Taek Oh; Young Taik Oh; Hye Jung Baik; So Young Park; Yu Seok Youn; Eun Seong Lee

doi:10.1039/c0cc03590d

A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)₂ peptide delivery

Bo Reum Lee
, Kyung Taek Oh
, Young Taik Oh
, Hye Jung Baik
, So Young Park
, Yu Seok Youn
, Eun Seong Lee

Department of Biomedical-Chemical Engineering

The Catholic University of Korea
Chung-Ang University
Yonsei University
Pusan National University

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-g-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

Original language	English
Pages (from-to)	3852-3854
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	13
DOIs	https://doi.org/10.1039/c0cc03590d
State	Published - 15 Mar 2011

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abstract = "We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as {\textquoteleft}GCS-g-DMA{\textquoteright} hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.",

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AU - Lee, Bo Reum

AU - Oh, Kyung Taek

AU - Oh, Young Taik

AU - Baik, Hye Jung

AU - Park, So Young

AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2011/3/15

Y1 - 2011/3/15

N2 - We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-g-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

AB - We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-g-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

UR - https://www.scopus.com/pages/publications/79952687474

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DO - 10.1039/c0cc03590d

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AN - SCOPUS:79952687474

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A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)₂ peptide delivery

Abstract

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