A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Nam Muk Oh; Kyung Taek Oh; Hye Jung Baik; Bo Reum Lee; A. Hyeong Lee; Yu Seok Youn; Eun Seong Lee

doi:10.1016/j.colsurfb.2010.02.023

A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Nam Muk Oh
, Kyung Taek Oh
, Hye Jung Baik
, Bo Reum Lee
, A. Hyeong Lee
, Yu Seok Youn
, Eun Seong Lee

Department of Biomedical-Chemical Engineering

The Catholic University of Korea
Chung-Ang University
Pusan National University

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pH_e), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pH_e) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pH_e.

Original language	English
Pages (from-to)	120-126
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2010.02.023
State	Published - 2010

Bibliographical note

Funding Information:
This work was supported by a grant from Korea Rural Development Administration, by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2009-0063870 ), by the Research Grant funded by the Gyeonggi Regional Research Center (GRRC) , and by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea.

Keywords

3-Diethylaminopropyl
Glycol chitosan
PH-responsive nanogel
Tumor extracellular pH

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10.1016/j.colsurfb.2010.02.023

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title = "A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation",

abstract = "In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pHe), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pHe) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pHe.",

keywords = "3-Diethylaminopropyl, Glycol chitosan, PH-responsive nanogel, Tumor extracellular pH",

author = "Oh, \{Nam Muk\} and Oh, \{Kyung Taek\} and Baik, \{Hye Jung\} and Lee, \{Bo Reum\} and Lee, \{A. Hyeong\} and Youn, \{Yu Seok\} and Lee, \{Eun Seong\}",

note = "Funding Information: This work was supported by a grant from Korea Rural Development Administration, by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2009-0063870 ), by the Research Grant funded by the Gyeonggi Regional Research Center (GRRC) , and by a grant from the Fundamental R\&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea.",

year = "2010",

doi = "10.1016/j.colsurfb.2010.02.023",

language = "English",

volume = "78",

pages = "120--126",

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T1 - A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting

T2 - In vitro evaluation

AU - Oh, Nam Muk

AU - Oh, Kyung Taek

AU - Baik, Hye Jung

AU - Lee, Bo Reum

AU - Lee, A. Hyeong

AU - Youn, Yu Seok

AU - Lee, Eun Seong

N1 - Funding Information: This work was supported by a grant from Korea Rural Development Administration, by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2009-0063870 ), by the Research Grant funded by the Gyeonggi Regional Research Center (GRRC) , and by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea.

PY - 2010

Y1 - 2010

N2 - In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pHe), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pHe) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pHe.

AB - In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pHe), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pHe) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pHe.

KW - 3-Diethylaminopropyl

KW - Glycol chitosan

KW - PH-responsive nanogel

KW - Tumor extracellular pH

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DO - 10.1016/j.colsurfb.2010.02.023

M3 - Article

C2 - 20299192

AN - SCOPUS:77950626930

SN - 0927-7765

VL - 78

SP - 120

EP - 126

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1

ER -

A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Abstract

Bibliographical note

Keywords

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