A smart polysaccharide/drug conjugate for photodynamic therapy

So Young Park; Hye Jung Baik; Young Taik Oh; Kyung Taek Oh; Yu Seok Youn; Eun Seong Lee

doi:10.1002/anie.201006038

A smart polysaccharide/drug conjugate for photodynamic therapy

So Young Park
, Hye Jung Baik
, Young Taik Oh
, Kyung Taek Oh
, Yu Seok Youn
, Eun Seong Lee

Department of Biomedical-Chemical Engineering

The Catholic University of Korea
Yonsei University
Chung-Ang University
Pusan National University

Research output: Contribution to journal › Article › peer-review

252 Scopus citations

Abstract

Sharper image: A newly developed polysaccharide/drug conjugate (see picture) responds to changes in pHa value and was shown to penetrate HeLa tumors in mice as determined by fluorescence imaging. It has the potential to be used in photodynamic therapy, thereby targeting the tumor while having no detrimental effects on the surrounding tissue.

Original language	English
Pages (from-to)	1644-1647
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	7
DOIs	https://doi.org/10.1002/anie.201006038
State	Published - 11 Feb 2011

Keywords

drug delivery
imaging agents
photodynamic therapy
polysaccharides

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10.1002/anie.201006038

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title = "A smart polysaccharide/drug conjugate for photodynamic therapy",

abstract = "Sharper image: A newly developed polysaccharide/drug conjugate (see picture) responds to changes in pHa value and was shown to penetrate HeLa tumors in mice as determined by fluorescence imaging. It has the potential to be used in photodynamic therapy, thereby targeting the tumor while having no detrimental effects on the surrounding tissue.",

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AU - Baik, Hye Jung

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AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2011/2/11

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AB - Sharper image: A newly developed polysaccharide/drug conjugate (see picture) responds to changes in pHa value and was shown to penetrate HeLa tumors in mice as determined by fluorescence imaging. It has the potential to be used in photodynamic therapy, thereby targeting the tumor while having no detrimental effects on the surrounding tissue.

KW - drug delivery

KW - imaging agents

KW - photodynamic therapy

KW - polysaccharides

UR - https://www.scopus.com/pages/publications/79851504323

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JO - Angewandte Chemie - International Edition

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A smart polysaccharide/drug conjugate for photodynamic therapy

Abstract

Keywords

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