A virus-mimetic nanogel vehicle

Eun Seong Lee; Dongin Kim; Yu Seok Youn; Kyung Taek Oh; You Han Bae

doi:10.1002/anie.200704121

A virus-mimetic nanogel vehicle

Eun Seong Lee
, Dongin Kim
, Yu Seok Youn
, Kyung Taek Oh
, You Han Bae

Department of Biomedical-Chemical Engineering

University of Utah

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Abstract

Delivering the goods: A pH-sensitive nanogel consists of a hydrophobic copolymer core and two layers of hydrophilic shell (see picture). The core is loaded with a model anticancer drug, doxorubicin (DOX). The nanogel infects tumor cells in a receptor-dependent manner, kills the cells, and migrates to neighboring cells like a virus. BSA = bovine serum albumin, F = folate, PEG = polyethylene glycol. (Figure Presented).

Original language	English
Pages (from-to)	2418-2421
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	13
DOIs	https://doi.org/10.1002/anie.200704121
State	Published - 14 Mar 2008

Keywords

Antitumor agents
Drug delivery
Gels
Nanotechnology
Viruses

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10.1002/anie.200704121

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title = "A virus-mimetic nanogel vehicle",

abstract = "Delivering the goods: A pH-sensitive nanogel consists of a hydrophobic copolymer core and two layers of hydrophilic shell (see picture). The core is loaded with a model anticancer drug, doxorubicin (DOX). The nanogel infects tumor cells in a receptor-dependent manner, kills the cells, and migrates to neighboring cells like a virus. BSA = bovine serum albumin, F = folate, PEG = polyethylene glycol. (Figure Presented).",

keywords = "Antitumor agents, Drug delivery, Gels, Nanotechnology, Viruses",

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PY - 2008/3/14

Y1 - 2008/3/14

N2 - Delivering the goods: A pH-sensitive nanogel consists of a hydrophobic copolymer core and two layers of hydrophilic shell (see picture). The core is loaded with a model anticancer drug, doxorubicin (DOX). The nanogel infects tumor cells in a receptor-dependent manner, kills the cells, and migrates to neighboring cells like a virus. BSA = bovine serum albumin, F = folate, PEG = polyethylene glycol. (Figure Presented).

AB - Delivering the goods: A pH-sensitive nanogel consists of a hydrophobic copolymer core and two layers of hydrophilic shell (see picture). The core is loaded with a model anticancer drug, doxorubicin (DOX). The nanogel infects tumor cells in a receptor-dependent manner, kills the cells, and migrates to neighboring cells like a virus. BSA = bovine serum albumin, F = folate, PEG = polyethylene glycol. (Figure Presented).

KW - Antitumor agents

KW - Drug delivery

KW - Gels

KW - Nanotechnology

KW - Viruses

UR - https://www.scopus.com/pages/publications/42449095909

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M3 - Article

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AN - SCOPUS:42449095909

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JO - Angewandte Chemie - International Edition

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A virus-mimetic nanogel vehicle

Abstract

Keywords

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