Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency

Yong Yeon Cho; Man Jong Kang; Hideyuki Sone; Takashi Suzuki; Makoto Abe; Miki Igarashi; Tomoyuki Tokunaga; Shigeki Ogawa; Yumiko A. Takei; Teruo Miyazawa; Hironobu Sasano; Takahiro Fujino; Tokuo T. Yamamoto

doi:10.1006/bbrc.2001.5065

Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency

Yong Yeon Cho, Man Jong Kang, Hideyuki Sone, Takashi Suzuki, Makoto Abe, Miki Igarashi, Tomoyuki Tokunaga, Shigeki Ogawa, Yumiko A. Takei, Teruo Miyazawa, Hironobu Sasano, Takahiro Fujino, Tokuo T. Yamamoto

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38 Scopus citations

Abstract

Arachidonate released by various stimuli is rapidly reesterified into membrane phospholipids initiated by acyl-CoA synthetase (ACS) and subsequent acyl-transfer reactions. ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid production. Female mice heterozygous for ACS4 deficiency become pregnant less frequently and produce small litters with extremely low transmission of the disrupted alleles. Striking morphological changes, including extremely enlarged uteri and lumina filled with numerous proliferative cysts of various sizes, were detected in ACS4+/- females. Furthermore, marked accumulation of prostaglandins was seen in the uterus of the heterozygous females. These results indicate that ACS4 modulates female fertility and uterine prostaglandin production.

Original language	English
Pages (from-to)	993-997
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	284
Issue number	4
DOIs	https://doi.org/10.1006/bbrc.2001.5065
State	Published - 2001

Bibliographical note

Funding Information:
We thank Dr. Ian Gleadall for review of the manuscript. This work was supported by Japan Society for Promotion of Science Grant RFTF97L00803.

Keywords

Acyl-CoA synthetase
Arachidonate
Prostaglandin
Reproduction

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10.1006/bbrc.2001.5065

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Cho, Y. Y., Kang, M. J., Sone, H., Suzuki, T., Abe, M., Igarashi, M., Tokunaga, T., Ogawa, S., Takei, Y. A., Miyazawa, T., Sasano, H., Fujino, T., & Yamamoto, T. T. (2001). Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency. Biochemical and Biophysical Research Communications, 284(4), 993-997. https://doi.org/10.1006/bbrc.2001.5065

@article{7be59fe5abcf4824aee055e1bae1ef2a,

title = "Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency",

abstract = "Arachidonate released by various stimuli is rapidly reesterified into membrane phospholipids initiated by acyl-CoA synthetase (ACS) and subsequent acyl-transfer reactions. ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid production. Female mice heterozygous for ACS4 deficiency become pregnant less frequently and produce small litters with extremely low transmission of the disrupted alleles. Striking morphological changes, including extremely enlarged uteri and lumina filled with numerous proliferative cysts of various sizes, were detected in ACS4+/- females. Furthermore, marked accumulation of prostaglandins was seen in the uterus of the heterozygous females. These results indicate that ACS4 modulates female fertility and uterine prostaglandin production.",

keywords = "Acyl-CoA synthetase, Arachidonate, Prostaglandin, Reproduction",

author = "Cho, {Yong Yeon} and Kang, {Man Jong} and Hideyuki Sone and Takashi Suzuki and Makoto Abe and Miki Igarashi and Tomoyuki Tokunaga and Shigeki Ogawa and Takei, {Yumiko A.} and Teruo Miyazawa and Hironobu Sasano and Takahiro Fujino and Yamamoto, {Tokuo T.}",

note = "Funding Information: We thank Dr. Ian Gleadall for review of the manuscript. This work was supported by Japan Society for Promotion of Science Grant RFTF97L00803.",

year = "2001",

doi = "10.1006/bbrc.2001.5065",

language = "English",

volume = "284",

pages = "993--997",

journal = "Biochemical and Biophysical Research Communications",

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Cho, YY, Kang, MJ, Sone, H, Suzuki, T, Abe, M, Igarashi, M, Tokunaga, T, Ogawa, S, Takei, YA, Miyazawa, T, Sasano, H, Fujino, T & Yamamoto, TT 2001, 'Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency', Biochemical and Biophysical Research Communications, vol. 284, no. 4, pp. 993-997. https://doi.org/10.1006/bbrc.2001.5065

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T1 - Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency

AU - Cho, Yong Yeon

AU - Kang, Man Jong

AU - Sone, Hideyuki

AU - Suzuki, Takashi

AU - Abe, Makoto

AU - Igarashi, Miki

AU - Tokunaga, Tomoyuki

AU - Ogawa, Shigeki

AU - Takei, Yumiko A.

AU - Miyazawa, Teruo

AU - Sasano, Hironobu

AU - Fujino, Takahiro

AU - Yamamoto, Tokuo T.

N1 - Funding Information: We thank Dr. Ian Gleadall for review of the manuscript. This work was supported by Japan Society for Promotion of Science Grant RFTF97L00803.

PY - 2001

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AB - Arachidonate released by various stimuli is rapidly reesterified into membrane phospholipids initiated by acyl-CoA synthetase (ACS) and subsequent acyl-transfer reactions. ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid production. Female mice heterozygous for ACS4 deficiency become pregnant less frequently and produce small litters with extremely low transmission of the disrupted alleles. Striking morphological changes, including extremely enlarged uteri and lumina filled with numerous proliferative cysts of various sizes, were detected in ACS4+/- females. Furthermore, marked accumulation of prostaglandins was seen in the uterus of the heterozygous females. These results indicate that ACS4 modulates female fertility and uterine prostaglandin production.

KW - Acyl-CoA synthetase

KW - Arachidonate

KW - Prostaglandin

KW - Reproduction

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DO - 10.1006/bbrc.2001.5065

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SN - 0006-291X

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Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency

Abstract

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Keywords

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