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Additive effect between quinine oxidoreductase gene (NQO1: Pro187Ser) and manganese superoxide dismutase gene (MnSOD: Ala-9Val) polymorphisms on tardive dyskinesia in patients with schizophrenia

  • Chi Un Pae

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

This study investigated whether there was an interaction between the NQO1 Pro187Ser and MnSOD Ala-9Val gene polymorphisms in the development of tardive dyskinesia (TD). The combined genotypes of T/T in NQO1 Pro187Ser and Val/Val in MnSOD Ala-9Val polymorphisms were found to be independently associated with a significantly higher risk of TD. However, further adequately powered studies will be needed to confirm these preliminary findings.

Original languageEnglish
Pages (from-to)336-338
Number of pages3
JournalPsychiatry Research
Volume161
Issue number3
DOIs
StatePublished - 15 Dec 2008

Bibliographical note

Funding Information:
This study was supported by a grant (KRF-2004-003-E00145) from the Korea Research Foundation.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Interaction polymorphism
  • MnSOD Ala-9Val
  • NQO1 Pro187Ser polymorphism
  • Tardive dyskinesia

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