Advanced Glycation End Products and Their Effect on Vascular Complications in Type 2 Diabetes Mellitus

Jeongmin Lee, Jae Seung Yun, Seung Hyun Ko

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Diabetes is well established as a chronic disease with a high health burden due to mortality or morbidity from the final outcomes of vascular complications. An increased duration of hyperglycemia is associated with abnormal metabolism. Advanced glycation end products (AGEs) are nonenzymatic glycated forms of free amino acids that lead to abnormal crosslinking of extra-cellular and intracellular proteins by disrupting the normal structure. Furthermore, the interaction of AGEs and their receptors induces several pathways by promoting oxidative stress and inflammation. In this review, we discuss the role of AGEs in diabetic vascular complications, especially type 2 DM, based on recent clinical studies.

Original languageEnglish
Article number3086
JournalNutrients
Volume14
Issue number15
DOIs
StatePublished - Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

  • advanced
  • chronic complication
  • diabetes mellitus
  • glycation end products
  • hyperglycemia
  • oxidative stress

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