Alendronate-modified hydroxyapatite nanoparticles for bone-specific dual delivery of drug and bone mineral

Seok Joon Hwang; Ji Seon Lee; Tae Kyung Ryu; Rae Hyung Kang; Ki Young Jeong; Dae Ryong Jun; Jung Min Koh; Sung Eun Kim; Sung Wook Choi

doi:10.1007/s13233-016-4094-5

Alendronate-modified hydroxyapatite nanoparticles for bone-specific dual delivery of drug and bone mineral

Seok Joon Hwang, Ji Seon Lee, Tae Kyung Ryu, Rae Hyung Kang, Ki Young Jeong, Dae Ryong Jun, Jung Min Koh, Sung Eun Kim, Sung Wook Choi

Biomedical Chemical Engineering

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Alendronate (Alen)-modified hydroxyapatite (HAp) nanoparticles with multilayers of poly(allylamine) (PAA) and alginate (ALG) were fabricated for bone-specific dual delivery of drug and mineral. Negatively charged HAp nanoparticles were coated with three layers of PAA and ALG using a layer-by-layer (LbL) method and then conjugated with Alen at the outmost layer of the LbL-coated HAp nanoparticles via carbodiimide chemistry. Alen-modified HAp nanoparticles had a spherical morphology and an average size of 61.5 nm. The superior adsorption property of the Alen-modified HAp nanoparticles was quantitatively confirmed using tricalcium phosphate disks as a bone model, compared to HAp nanoparticles. Cell culture assays revealed a higher proliferation rate and alkaline phosphatase activity of osteoblasts treated with the Alen-modified HAp nanoparticles. [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	623-628
Number of pages	6
Journal	Macromolecular Research
Volume	24
Issue number	7
DOIs	https://doi.org/10.1007/s13233-016-4094-5
State	Published - 1 Jul 2016

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Publisher Copyright:
© 2016, The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht.

Keywords

alendronate
dual targeted delivery
hydroxyapatite
layer-by-layer method

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10.1007/s13233-016-4094-5

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title = "Alendronate-modified hydroxyapatite nanoparticles for bone-specific dual delivery of drug and bone mineral",

abstract = "Alendronate (Alen)-modified hydroxyapatite (HAp) nanoparticles with multilayers of poly(allylamine) (PAA) and alginate (ALG) were fabricated for bone-specific dual delivery of drug and mineral. Negatively charged HAp nanoparticles were coated with three layers of PAA and ALG using a layer-by-layer (LbL) method and then conjugated with Alen at the outmost layer of the LbL-coated HAp nanoparticles via carbodiimide chemistry. Alen-modified HAp nanoparticles had a spherical morphology and an average size of 61.5 nm. The superior adsorption property of the Alen-modified HAp nanoparticles was quantitatively confirmed using tricalcium phosphate disks as a bone model, compared to HAp nanoparticles. Cell culture assays revealed a higher proliferation rate and alkaline phosphatase activity of osteoblasts treated with the Alen-modified HAp nanoparticles. [Figure not available: see fulltext.]",

keywords = "alendronate, dual targeted delivery, hydroxyapatite, layer-by-layer method",

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note = "Publisher Copyright: {\textcopyright} 2016, The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht.",

year = "2016",

month = jul,

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doi = "10.1007/s13233-016-4094-5",

language = "English",

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T1 - Alendronate-modified hydroxyapatite nanoparticles for bone-specific dual delivery of drug and bone mineral

AU - Hwang, Seok Joon

AU - Lee, Ji Seon

AU - Ryu, Tae Kyung

AU - Kang, Rae Hyung

AU - Jeong, Ki Young

AU - Jun, Dae Ryong

AU - Koh, Jung Min

AU - Kim, Sung Eun

AU - Choi, Sung Wook

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Alendronate (Alen)-modified hydroxyapatite (HAp) nanoparticles with multilayers of poly(allylamine) (PAA) and alginate (ALG) were fabricated for bone-specific dual delivery of drug and mineral. Negatively charged HAp nanoparticles were coated with three layers of PAA and ALG using a layer-by-layer (LbL) method and then conjugated with Alen at the outmost layer of the LbL-coated HAp nanoparticles via carbodiimide chemistry. Alen-modified HAp nanoparticles had a spherical morphology and an average size of 61.5 nm. The superior adsorption property of the Alen-modified HAp nanoparticles was quantitatively confirmed using tricalcium phosphate disks as a bone model, compared to HAp nanoparticles. Cell culture assays revealed a higher proliferation rate and alkaline phosphatase activity of osteoblasts treated with the Alen-modified HAp nanoparticles. [Figure not available: see fulltext.]

AB - Alendronate (Alen)-modified hydroxyapatite (HAp) nanoparticles with multilayers of poly(allylamine) (PAA) and alginate (ALG) were fabricated for bone-specific dual delivery of drug and mineral. Negatively charged HAp nanoparticles were coated with three layers of PAA and ALG using a layer-by-layer (LbL) method and then conjugated with Alen at the outmost layer of the LbL-coated HAp nanoparticles via carbodiimide chemistry. Alen-modified HAp nanoparticles had a spherical morphology and an average size of 61.5 nm. The superior adsorption property of the Alen-modified HAp nanoparticles was quantitatively confirmed using tricalcium phosphate disks as a bone model, compared to HAp nanoparticles. Cell culture assays revealed a higher proliferation rate and alkaline phosphatase activity of osteoblasts treated with the Alen-modified HAp nanoparticles. [Figure not available: see fulltext.]

KW - alendronate

KW - dual targeted delivery

KW - hydroxyapatite

KW - layer-by-layer method

UR - https://www.scopus.com/pages/publications/84976487063

U2 - 10.1007/s13233-016-4094-5

DO - 10.1007/s13233-016-4094-5

M3 - Article

AN - SCOPUS:84976487063

SN - 1598-5032

VL - 24

SP - 623

EP - 628

JO - Macromolecular Research

JF - Macromolecular Research

IS - 7

ER -

Alendronate-modified hydroxyapatite nanoparticles for bone-specific dual delivery of drug and bone mineral

Abstract

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Keywords

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