Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

Jin S. Im; Tae Jin Kang; Seong Beom Lee; Chi Hong Kim; Sang Haak Lee; Manjunatha M. Venkataswamy; Evan R. Serfass; Bing Chen; Petr A. Illarionov; Gurdyal S. Besra; William R. Jacobs; Gue Tae Chae; Steven A. Porcelli

doi:10.1016/j.clim.2007.12.005

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

Jin S. Im
, Tae Jin Kang
, Seong Beom Lee
, Chi Hong Kim
, Sang Haak Lee
, Manjunatha M. Venkataswamy
, Evan R. Serfass
, Bing Chen
, Petr A. Illarionov
, Gurdyal S. Besra
, William R. Jacobs
, Gue Tae Chae
, Steven A. Porcelli

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4^-CD8β^- (DN) iNKT cells with a proportionate increase in the CD4⁺ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.

Original language	English
Pages (from-to)	214-224
Number of pages	11
Journal	Clinical Immunology
Volume	127
Issue number	2
DOIs	https://doi.org/10.1016/j.clim.2007.12.005
State	Published - May 2008

Bibliographical note

Funding Information:
This work was supported by grants to S.A.P. from the NIH (AI063537 and AI45889). S.A.P. received partial support from an Irma T. Hirschl Career Scientist Award. GSB acknowledges support in the form of a Personal Research Chair from Mr. James Bardrick, a Royal Society Wolfson Research Merit Award, as a former Lister Institute-Jenner Research Fellow, the Medical Research Council (G9901077 and G0500590) and The Wellcome Trust (081569/2/06/2). E.S. was supported by the Medical Scientist Training Program of the Albert Einstein College of Medicine. Flow cytometry studies were supported by the FACS Core Facilities of the Center for AIDS Research at the Albert Einstein College of Medicine and Montefiore Medical Center (NIH/NIAID AI51519) and the Albert Einstein Cancer Center (NIH/NCI P30 CA13330).

Keywords

CD1d
Glycolipid
Invariant natural killer T cells
Leprosy
Mycobacteria
Tuberculosis
α-Galactosylceramide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clim.2007.12.005

Cite this

Im, J. S., Kang, T. J., Lee, S. B., Kim, C. H., Lee, S. H., Venkataswamy, M. M., Serfass, E. R., Chen, B., Illarionov, P. A., Besra, G. S., Jacobs, W. R., Chae, G. T., & Porcelli, S. A. (2008). Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. Clinical Immunology, 127(2), 214-224. https://doi.org/10.1016/j.clim.2007.12.005

@article{1913097d1c534bb0aa12dd26efa77ad4,

title = "Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections",

abstract = "CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4-CD8β- (DN) iNKT cells with a proportionate increase in the CD4+ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.",

keywords = "CD1d, Glycolipid, Invariant natural killer T cells, Leprosy, Mycobacteria, Tuberculosis, α-Galactosylceramide",

author = "Im, \{Jin S.\} and Kang, \{Tae Jin\} and Lee, \{Seong Beom\} and Kim, \{Chi Hong\} and Lee, \{Sang Haak\} and Venkataswamy, \{Manjunatha M.\} and Serfass, \{Evan R.\} and Bing Chen and Illarionov, \{Petr A.\} and Besra, \{Gurdyal S.\} and Jacobs, \{William R.\} and Chae, \{Gue Tae\} and Porcelli, \{Steven A.\}",

note = "Funding Information: This work was supported by grants to S.A.P. from the NIH (AI063537 and AI45889). S.A.P. received partial support from an Irma T. Hirschl Career Scientist Award. GSB acknowledges support in the form of a Personal Research Chair from Mr. James Bardrick, a Royal Society Wolfson Research Merit Award, as a former Lister Institute-Jenner Research Fellow, the Medical Research Council (G9901077 and G0500590) and The Wellcome Trust (081569/2/06/2). E.S. was supported by the Medical Scientist Training Program of the Albert Einstein College of Medicine. Flow cytometry studies were supported by the FACS Core Facilities of the Center for AIDS Research at the Albert Einstein College of Medicine and Montefiore Medical Center (NIH/NIAID AI51519) and the Albert Einstein Cancer Center (NIH/NCI P30 CA13330).",

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AU - Im, Jin S.

AU - Kang, Tae Jin

AU - Lee, Seong Beom

AU - Kim, Chi Hong

AU - Lee, Sang Haak

AU - Venkataswamy, Manjunatha M.

AU - Serfass, Evan R.

AU - Chen, Bing

AU - Illarionov, Petr A.

AU - Besra, Gurdyal S.

AU - Jacobs, William R.

AU - Chae, Gue Tae

AU - Porcelli, Steven A.

N1 - Funding Information: This work was supported by grants to S.A.P. from the NIH (AI063537 and AI45889). S.A.P. received partial support from an Irma T. Hirschl Career Scientist Award. GSB acknowledges support in the form of a Personal Research Chair from Mr. James Bardrick, a Royal Society Wolfson Research Merit Award, as a former Lister Institute-Jenner Research Fellow, the Medical Research Council (G9901077 and G0500590) and The Wellcome Trust (081569/2/06/2). E.S. was supported by the Medical Scientist Training Program of the Albert Einstein College of Medicine. Flow cytometry studies were supported by the FACS Core Facilities of the Center for AIDS Research at the Albert Einstein College of Medicine and Montefiore Medical Center (NIH/NIAID AI51519) and the Albert Einstein Cancer Center (NIH/NCI P30 CA13330).

PY - 2008/5

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N2 - CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4-CD8β- (DN) iNKT cells with a proportionate increase in the CD4+ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.

AB - CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4-CD8β- (DN) iNKT cells with a proportionate increase in the CD4+ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.

KW - CD1d

KW - Glycolipid

KW - Invariant natural killer T cells

KW - Leprosy

KW - Mycobacteria

KW - Tuberculosis

KW - α-Galactosylceramide

UR - https://www.scopus.com/pages/publications/41549168084

U2 - 10.1016/j.clim.2007.12.005

DO - 10.1016/j.clim.2007.12.005

M3 - Article

C2 - 18308638

AN - SCOPUS:41549168084

SN - 1521-6616

VL - 127

SP - 214

EP - 224

JO - Clinical Immunology

JF - Clinical Immunology

IS - 2

ER -

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

Abstract

Bibliographical note

Keywords

UN SDGs

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