Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction

Hyungsup Kim; Hyesu Kim; Luan Thien Nguyen; Taewoong Ha; Sujin Lim; Kyungmin Kim; Soon Ho Kim; Kyungreem Han; Seung Jae Hyeon; Hoon Ryu; Yong Soo Park; Sang Hyun Kim; In Beom Kim; Gyu Sang Hong; Seung Eun Lee; Yunsook Choi; Lawrence B. Cohen; Uhtaek Oh

doi:10.1016/j.pneurobio.2022.102369

Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction

Hyungsup Kim, Hyesu Kim, Luan Thien Nguyen, Taewoong Ha, Sujin Lim, Kyungmin Kim, Soon Ho Kim, Kyungreem Han, Seung Jae Hyeon, Hoon Ryu, Yong Soo Park, Sang Hyun Kim, In Beom Kim, Gyu Sang Hong, Seung Eun Lee, Yunsook Choi, Lawrence B. Cohen, Uhtaek Oh

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory neurons in the olfactory epithelium (OE) detect odorants, where cAMP and Ca²⁺ play a significant role in transducing odorant inputs to electrical activity. Here we show Anoctamin 9, a cation channel activated by cAMP/PKA pathway, is expressed in the OE and amplifies olfactory signals. Ano9-deficient mice had reduced olfactory behavioral sensitivity, electro-olfactogram signals, and neural activity in the olfactory bulb. In line with the difference in olfaction between birds and other vertebrates, chick ANO9 failed to respond to odorants, whereas chick CNGA2, a major transduction channel, showed greater responses to cAMP. Thus, we concluded that the signal amplification by ANO9 is important for mammalian olfactory transduction.

Original language	English
Article number	102369
Journal	Progress in Neurobiology
Volume	219
DOIs	https://doi.org/10.1016/j.pneurobio.2022.102369
State	Published - Dec 2022

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation of Korea ( 2020R1A3A300192911 ).

Publisher Copyright:
© 2022

Keywords

Amplification
Anoctamin 9
Cation channel
Olfaction
TMEM16J
cAMP

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Kim, H., Kim, H., Nguyen, L. T., Ha, T., Lim, S., Kim, K., Kim, S. H., Han, K., Hyeon, S. J., Ryu, H., Park, Y. S., Kim, S. H., Kim, I. B., Hong, G. S., Lee, S. E., Choi, Y., Cohen, L. B., & Oh, U. (2022). Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction. Progress in Neurobiology, 219, Article 102369. https://doi.org/10.1016/j.pneurobio.2022.102369

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title = "Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction",

abstract = "Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory neurons in the olfactory epithelium (OE) detect odorants, where cAMP and Ca2+ play a significant role in transducing odorant inputs to electrical activity. Here we show Anoctamin 9, a cation channel activated by cAMP/PKA pathway, is expressed in the OE and amplifies olfactory signals. Ano9-deficient mice had reduced olfactory behavioral sensitivity, electro-olfactogram signals, and neural activity in the olfactory bulb. In line with the difference in olfaction between birds and other vertebrates, chick ANO9 failed to respond to odorants, whereas chick CNGA2, a major transduction channel, showed greater responses to cAMP. Thus, we concluded that the signal amplification by ANO9 is important for mammalian olfactory transduction.",

keywords = "Amplification, Anoctamin 9, Cation channel, Olfaction, TMEM16J, cAMP",

author = "Hyungsup Kim and Hyesu Kim and Nguyen, {Luan Thien} and Taewoong Ha and Sujin Lim and Kyungmin Kim and Kim, {Soon Ho} and Kyungreem Han and Hyeon, {Seung Jae} and Hoon Ryu and Park, {Yong Soo} and Kim, {Sang Hyun} and Kim, {In Beom} and Hong, {Gyu Sang} and Lee, {Seung Eun} and Yunsook Choi and Cohen, {Lawrence B.} and Uhtaek Oh",

note = "Funding Information: This study was supported by the National Research Foundation of Korea ( 2020R1A3A300192911 ). Publisher Copyright: {\textcopyright} 2022",

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doi = "10.1016/j.pneurobio.2022.102369",

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AU - Kim, Kyungmin

AU - Kim, Soon Ho

AU - Han, Kyungreem

AU - Hyeon, Seung Jae

AU - Ryu, Hoon

AU - Park, Yong Soo

AU - Kim, Sang Hyun

AU - Kim, In Beom

AU - Hong, Gyu Sang

AU - Lee, Seung Eun

AU - Choi, Yunsook

AU - Cohen, Lawrence B.

AU - Oh, Uhtaek

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AB - Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory neurons in the olfactory epithelium (OE) detect odorants, where cAMP and Ca2+ play a significant role in transducing odorant inputs to electrical activity. Here we show Anoctamin 9, a cation channel activated by cAMP/PKA pathway, is expressed in the OE and amplifies olfactory signals. Ano9-deficient mice had reduced olfactory behavioral sensitivity, electro-olfactogram signals, and neural activity in the olfactory bulb. In line with the difference in olfaction between birds and other vertebrates, chick ANO9 failed to respond to odorants, whereas chick CNGA2, a major transduction channel, showed greater responses to cAMP. Thus, we concluded that the signal amplification by ANO9 is important for mammalian olfactory transduction.

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KW - Cation channel

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Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction

Abstract

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Keywords

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