An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

So Young Park; Kyung Taek Oh; Young Taik Oh; Nam Muk Oh; Yu Seok Youn; Eun Seong Lee

doi:10.1039/c2cc16087k

An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

So Young Park
, Kyung Taek Oh
, Young Taik Oh
, Nam Muk Oh
, Yu Seok Youn
, Eun Seong Lee

Department of Biomedical-Chemical Engineering

The Catholic University of Korea
Chung-Ang University
Yonsei University
Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.

Original language	English
Pages (from-to)	2522-2524
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	19
DOIs	https://doi.org/10.1039/c2cc16087k
State	Published - 6 Feb 2012

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10.1039/c2cc16087k

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title = "An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy",

abstract = "We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.",

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AU - Park, So Young

AU - Oh, Kyung Taek

AU - Oh, Young Taik

AU - Oh, Nam Muk

AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2012/2/6

Y1 - 2012/2/6

N2 - We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.

AB - We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.

UR - https://www.scopus.com/pages/publications/84863116023

U2 - 10.1039/c2cc16087k

DO - 10.1039/c2cc16087k

M3 - Article

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AN - SCOPUS:84863116023

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SP - 2522

EP - 2524

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

Abstract

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