An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation

Soon Kyu Lee; Jong Young Choi; Eun Sun Jung; Jung Hyun Kwon; Jeong Won Jang; Si Hyun Bae; Seung Kew Yoon

doi:10.3390/ijms24055002

An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation

Soon Kyu Lee, Jong Young Choi, Eun Sun Jung, Jung Hyun Kwon, Jeong Won Jang, Si Hyun Bae, Seung Kew Yoon

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The liver is frequently exposed to potentially toxic materials, and it is the primary site of clearance of foreign agents, along with many innate and adaptive immune cells. Subsequently, drug induced liver injury (DILI), which is caused by medications, herbs, and dietary supplements, often occurs and has become an important issue in liver diseases. Reactive metabolites or drug–protein complexes induce DILI via the activation of various innate and adaptive immune cells. There has been a revolutionary development of treatment drugs for hepatocellular carcinoma (HCC) and liver transplantation (LT), including immune checkpoint inhibitors (ICIs), that show high efficacy in patients with advanced HCC. Along with the high efficacy of novel drugs, DILI has become a pivotal issue in the use of new drugs, including ICIs. This review demonstrates the immunological mechanism of DILI, including the innate and adaptive immune systems. Moreover, it aims to provide drug treatment targets, describe the mechanisms of DILI, and detail the management of DILI caused by drugs for HCC and LT.

Original language	English
Article number	5002
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	5
DOIs	https://doi.org/10.3390/ijms24055002
State	Published - Mar 2023

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (no. 2021R1I1A1A01050954; S.K.L.). This study was also supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence, Incheon St. Mary’s Hospital, The Catholic University of Korea.

Publisher Copyright:
© 2023 by the authors.

Keywords

B cell
hepatocellular carcinoma
hepatotoxicity
immune checkpoint inhibitors
immunosuppressant
injury
macrophage
microenvironment
T cell
tyrosine kinase inhibitors

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10.3390/ijms24055002

Cite this

@article{f124980d3f614c68b03fb343bae84786,

title = "An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation",

abstract = "The liver is frequently exposed to potentially toxic materials, and it is the primary site of clearance of foreign agents, along with many innate and adaptive immune cells. Subsequently, drug induced liver injury (DILI), which is caused by medications, herbs, and dietary supplements, often occurs and has become an important issue in liver diseases. Reactive metabolites or drug–protein complexes induce DILI via the activation of various innate and adaptive immune cells. There has been a revolutionary development of treatment drugs for hepatocellular carcinoma (HCC) and liver transplantation (LT), including immune checkpoint inhibitors (ICIs), that show high efficacy in patients with advanced HCC. Along with the high efficacy of novel drugs, DILI has become a pivotal issue in the use of new drugs, including ICIs. This review demonstrates the immunological mechanism of DILI, including the innate and adaptive immune systems. Moreover, it aims to provide drug treatment targets, describe the mechanisms of DILI, and detail the management of DILI caused by drugs for HCC and LT.",

keywords = "B cell, hepatocellular carcinoma, hepatotoxicity, immune checkpoint inhibitors, immunosuppressant, injury, macrophage, microenvironment, T cell, tyrosine kinase inhibitors",

author = "Lee, {Soon Kyu} and Choi, {Jong Young} and Jung, {Eun Sun} and Kwon, {Jung Hyun} and Jang, {Jeong Won} and Bae, {Si Hyun} and Yoon, {Seung Kew}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (no. 2021R1I1A1A01050954; S.K.L.). This study was also supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence, Incheon St. Mary{\textquoteright}s Hospital, The Catholic University of Korea. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

doi = "10.3390/ijms24055002",

language = "English",

volume = "24",

journal = "International Journal of Molecular Sciences",

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An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation. / Lee, Soon Kyu; Choi, Jong Young; Jung, Eun Sun et al.
In: International Journal of Molecular Sciences, Vol. 24, No. 5, 5002, 03.2023.

Research output: Contribution to journal › Review article › peer-review

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T1 - An Immunological Perspective on the Mechanism of Drug Induced Liver Injury

T2 - Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation

AU - Lee, Soon Kyu

AU - Choi, Jong Young

AU - Jung, Eun Sun

AU - Kwon, Jung Hyun

AU - Jang, Jeong Won

AU - Bae, Si Hyun

AU - Yoon, Seung Kew

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (no. 2021R1I1A1A01050954; S.K.L.). This study was also supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence, Incheon St. Mary’s Hospital, The Catholic University of Korea. Publisher Copyright: © 2023 by the authors.

PY - 2023/3

Y1 - 2023/3

N2 - The liver is frequently exposed to potentially toxic materials, and it is the primary site of clearance of foreign agents, along with many innate and adaptive immune cells. Subsequently, drug induced liver injury (DILI), which is caused by medications, herbs, and dietary supplements, often occurs and has become an important issue in liver diseases. Reactive metabolites or drug–protein complexes induce DILI via the activation of various innate and adaptive immune cells. There has been a revolutionary development of treatment drugs for hepatocellular carcinoma (HCC) and liver transplantation (LT), including immune checkpoint inhibitors (ICIs), that show high efficacy in patients with advanced HCC. Along with the high efficacy of novel drugs, DILI has become a pivotal issue in the use of new drugs, including ICIs. This review demonstrates the immunological mechanism of DILI, including the innate and adaptive immune systems. Moreover, it aims to provide drug treatment targets, describe the mechanisms of DILI, and detail the management of DILI caused by drugs for HCC and LT.

AB - The liver is frequently exposed to potentially toxic materials, and it is the primary site of clearance of foreign agents, along with many innate and adaptive immune cells. Subsequently, drug induced liver injury (DILI), which is caused by medications, herbs, and dietary supplements, often occurs and has become an important issue in liver diseases. Reactive metabolites or drug–protein complexes induce DILI via the activation of various innate and adaptive immune cells. There has been a revolutionary development of treatment drugs for hepatocellular carcinoma (HCC) and liver transplantation (LT), including immune checkpoint inhibitors (ICIs), that show high efficacy in patients with advanced HCC. Along with the high efficacy of novel drugs, DILI has become a pivotal issue in the use of new drugs, including ICIs. This review demonstrates the immunological mechanism of DILI, including the innate and adaptive immune systems. Moreover, it aims to provide drug treatment targets, describe the mechanisms of DILI, and detail the management of DILI caused by drugs for HCC and LT.

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KW - hepatocellular carcinoma

KW - hepatotoxicity

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KW - immunosuppressant

KW - injury

KW - macrophage

KW - microenvironment

KW - T cell

KW - tyrosine kinase inhibitors

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U2 - 10.3390/ijms24055002

DO - 10.3390/ijms24055002

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SN - 1661-6596

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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M1 - 5002

ER -

An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation

Abstract

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Keywords

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Research from Catholic University of Korea in the Area of Drug-Induced Liver Injury Published (An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver ...)

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An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation

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Bibliographical note

Keywords

Access to Document

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Research from Catholic University of Korea in the Area of Drug-Induced Liver Injury Published (An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver ...)

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