Antinociceptive effects of botulinum toxin A for the treatment of neuropathic pain

Jung Park Hue; Eon Moon Dong

doi:10.3727/154296108783994040

Antinociceptive effects of botulinum toxin A for the treatment of neuropathic pain

Jung Park Hue, Eon Moon Dong

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Botulinum toxin type A (BoNT-A) has been used to treat many disorders related to excessive muscle contraction. Recent clinical reports suggest that BoNT-A is effective at treating the neuropathic pains associated with multiple sclerosis, postherpetic neuralgia, peripheral neuropathy and the severe tingling caused by herniation of cervical vertebrae. In addition, the peripheral application of BoNT-A was found to have an antiallodynic effect in a rat neuropathic model. Although its precise mechanism of pain relief is not completely understood, BoNT-A may reduce the activities of various substances that sensitize nociceptors. Moreover, the use of BoNT-A as a novel analgesic is providing hope to patients with intractable chronic pain, especially neuropathic pain.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Reviews in Analgesia
Volume	10
Issue number	1
DOIs	https://doi.org/10.3727/154296108783994040
State	Published - 2008

Keywords

Botulinum toxin type A
Neuropathic pain

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abstract = "Botulinum toxin type A (BoNT-A) has been used to treat many disorders related to excessive muscle contraction. Recent clinical reports suggest that BoNT-A is effective at treating the neuropathic pains associated with multiple sclerosis, postherpetic neuralgia, peripheral neuropathy and the severe tingling caused by herniation of cervical vertebrae. In addition, the peripheral application of BoNT-A was found to have an antiallodynic effect in a rat neuropathic model. Although its precise mechanism of pain relief is not completely understood, BoNT-A may reduce the activities of various substances that sensitize nociceptors. Moreover, the use of BoNT-A as a novel analgesic is providing hope to patients with intractable chronic pain, especially neuropathic pain.",

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AB - Botulinum toxin type A (BoNT-A) has been used to treat many disorders related to excessive muscle contraction. Recent clinical reports suggest that BoNT-A is effective at treating the neuropathic pains associated with multiple sclerosis, postherpetic neuralgia, peripheral neuropathy and the severe tingling caused by herniation of cervical vertebrae. In addition, the peripheral application of BoNT-A was found to have an antiallodynic effect in a rat neuropathic model. Although its precise mechanism of pain relief is not completely understood, BoNT-A may reduce the activities of various substances that sensitize nociceptors. Moreover, the use of BoNT-A as a novel analgesic is providing hope to patients with intractable chronic pain, especially neuropathic pain.

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Antinociceptive effects of botulinum toxin A for the treatment of neuropathic pain

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Keywords

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