Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population

Huy Gia Vuong; Ayana Suzuki; Hee Young Na; Pham Van Tuyen; Doan Minh Khuy; Hiep Canh Nguyen; Tikamporn Jitpasutham; Agustina Abelardo; Takashi Amano; So Yeon Park; Chan Kwon Jung; Mitsuyoshi Hirokawa; Ryohei Katoh; Kennichi Kakudo; Andrey Bychkov

doi:10.1093/ajcp/aqaa182

Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population

Huy Gia Vuong
, Ayana Suzuki
, Hee Young Na
, Pham Van Tuyen
, Doan Minh Khuy
, Hiep Canh Nguyen
, Tikamporn Jitpasutham
, Agustina Abelardo
, Takashi Amano
, So Yeon Park
, Chan Kwon Jung
, Mitsuyoshi Hirokawa
, Ryohei Katoh
, Kennichi Kakudo
, Andrey Bychkov

Department of Hospital Pathology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objectives: We aimed to provide the Asian experience with the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules. Methods: Consecutive thyroid fine-needle aspirates (patient age, ≤18 years) were retrospectively collected from 7 tertiary centers in 5 Asian countries. Results: Of 194,364 thyroid aspirates, 0.6% were pediatric cases (mean age, 15.0 years). Among 827 nodules with accessible follow-up, the resection rate and risk of malignancy (ROM) were 36.3% and 59.0%, respectively. Malignant nodules (n = 179) accounted for 59.7% of resected nodules and 21.6% of all thyroid nodules with available follow-up. Compared with the published adult series, pediatric nodules had a higher resection rate and ROM, particularly in the indeterminate categories. Conclusions: Our study demonstrates that Asian pediatric thyroid nodules had higher ROM than those from adults. The prototypic outputs of TBSRTC may need to be adjusted in the pediatric population.

Original language	English
Pages (from-to)	680-689
Number of pages	10
Journal	American Journal of Clinical Pathology
Volume	155
Issue number	5
DOIs	https://doi.org/10.1093/ajcp/aqaa182
State	Published - 1 May 2021

Bibliographical note

Publisher Copyright:
© 2020 American Society for Clinical Pathology, 2020. All rights reserved.

Keywords

Children
Fine-needle aspiration
Pediatric
Resection rate
Risk of malignancy
The Bethesda System
Thyroid
Thyroid cancer
Thyroid nodules

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ajcp/aqaa182

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Vuong, H. G., Suzuki, A., Na, H. Y., Tuyen, P. V., Khuy, D. M., Nguyen, H. C., Jitpasutham, T., Abelardo, A., Amano, T., Park, S. Y., Jung, C. K., Hirokawa, M., Katoh, R., Kakudo, K., & Bychkov, A. (2021). Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population. American Journal of Clinical Pathology, 155(5), 680-689. https://doi.org/10.1093/ajcp/aqaa182

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abstract = "Objectives: We aimed to provide the Asian experience with the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules. Methods: Consecutive thyroid fine-needle aspirates (patient age, ≤18 years) were retrospectively collected from 7 tertiary centers in 5 Asian countries. Results: Of 194,364 thyroid aspirates, 0.6\% were pediatric cases (mean age, 15.0 years). Among 827 nodules with accessible follow-up, the resection rate and risk of malignancy (ROM) were 36.3\% and 59.0\%, respectively. Malignant nodules (n = 179) accounted for 59.7\% of resected nodules and 21.6\% of all thyroid nodules with available follow-up. Compared with the published adult series, pediatric nodules had a higher resection rate and ROM, particularly in the indeterminate categories. Conclusions: Our study demonstrates that Asian pediatric thyroid nodules had higher ROM than those from adults. The prototypic outputs of TBSRTC may need to be adjusted in the pediatric population.",

keywords = "Children, Fine-needle aspiration, Pediatric, Resection rate, Risk of malignancy, The Bethesda System, Thyroid, Thyroid cancer, Thyroid nodules",

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Vuong, HG, Suzuki, A, Na, HY, Tuyen, PV, Khuy, DM, Nguyen, HC, Jitpasutham, T, Abelardo, A, Amano, T, Park, SY, Jung, CK, Hirokawa, M, Katoh, R, Kakudo, K & Bychkov, A 2021, 'Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population', American Journal of Clinical Pathology, vol. 155, no. 5, pp. 680-689. https://doi.org/10.1093/ajcp/aqaa182

TY - JOUR

T1 - Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population

AU - Vuong, Huy Gia

AU - Suzuki, Ayana

AU - Na, Hee Young

AU - Tuyen, Pham Van

AU - Khuy, Doan Minh

AU - Nguyen, Hiep Canh

AU - Jitpasutham, Tikamporn

AU - Abelardo, Agustina

AU - Amano, Takashi

AU - Park, So Yeon

AU - Jung, Chan Kwon

AU - Hirokawa, Mitsuyoshi

AU - Katoh, Ryohei

AU - Kakudo, Kennichi

AU - Bychkov, Andrey

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Objectives: We aimed to provide the Asian experience with the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules. Methods: Consecutive thyroid fine-needle aspirates (patient age, ≤18 years) were retrospectively collected from 7 tertiary centers in 5 Asian countries. Results: Of 194,364 thyroid aspirates, 0.6% were pediatric cases (mean age, 15.0 years). Among 827 nodules with accessible follow-up, the resection rate and risk of malignancy (ROM) were 36.3% and 59.0%, respectively. Malignant nodules (n = 179) accounted for 59.7% of resected nodules and 21.6% of all thyroid nodules with available follow-up. Compared with the published adult series, pediatric nodules had a higher resection rate and ROM, particularly in the indeterminate categories. Conclusions: Our study demonstrates that Asian pediatric thyroid nodules had higher ROM than those from adults. The prototypic outputs of TBSRTC may need to be adjusted in the pediatric population.

AB - Objectives: We aimed to provide the Asian experience with the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules. Methods: Consecutive thyroid fine-needle aspirates (patient age, ≤18 years) were retrospectively collected from 7 tertiary centers in 5 Asian countries. Results: Of 194,364 thyroid aspirates, 0.6% were pediatric cases (mean age, 15.0 years). Among 827 nodules with accessible follow-up, the resection rate and risk of malignancy (ROM) were 36.3% and 59.0%, respectively. Malignant nodules (n = 179) accounted for 59.7% of resected nodules and 21.6% of all thyroid nodules with available follow-up. Compared with the published adult series, pediatric nodules had a higher resection rate and ROM, particularly in the indeterminate categories. Conclusions: Our study demonstrates that Asian pediatric thyroid nodules had higher ROM than those from adults. The prototypic outputs of TBSRTC may need to be adjusted in the pediatric population.

KW - Children

KW - Fine-needle aspiration

KW - Pediatric

KW - Resection rate

KW - Risk of malignancy

KW - The Bethesda System

KW - Thyroid

KW - Thyroid cancer

KW - Thyroid nodules

UR - https://www.scopus.com/pages/publications/85105763292

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M3 - Article

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AN - SCOPUS:85105763292

SN - 0002-9173

VL - 155

SP - 680

EP - 689

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

IS - 5

ER -

Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population

Abstract

Bibliographical note

Keywords

UN SDGs

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