Assessment of malignancy in gliomas by 3T 1H MR spectroscopy

Sin Soo Jeun; Moon Chan Kim; Bum Soo Kim; Jae Mun Lee; Sung Taek Chung; Chang Hyun Oh; Soo Yeol Lee; Bo Young Choe

doi:10.1016/j.clinimag.2004.03.004

Assessment of malignancy in gliomas by 3T ¹H MR spectroscopy

Sin Soo Jeun
, Moon Chan Kim
, Bum Soo Kim
, Jae Mun Lee
, Sung Taek Chung
, Chang Hyun Oh
, Soo Yeol Lee
, Bo Young Choe

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The purpose of this study was to assess clinical ¹H MR spectroscopy (MRS) as a noninvasive method for evaluating brain tumor malignancy at 3T high-field system. Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumor (i.e., gliomas) was employed to evaluate spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cr) and lactate. On the basis of Cr, these peak areas were quantitated as a relative ratio. The variation of metabolite measurements of the designated region in 10 normal volunteers was less than 10%. Normal ranges of NAA/Cr and Cho/Cr ratios were 1.67±018 and 1.16±0.15, respectively. NAA/Cr ratio of gliomas was significantly lower than that of the normal tissues (P=.005), but Cho/Cr ratio of gliomas was significantly higher (P=.001). Cho/Cr ratio of high-grade gliomas was significantly higher than that of low-grade gliomas. The present study demonstrated that the neuronal degradation or loss was observed in all gliomas. Higher-grade glioma was correlated with higher Cho/Cr ratio, indicating a significant dependence of Cho levels on malignancy of gliomas. Our results suggest that clinical ¹H MR spectroscopy could be useful to predict tumor malignancy.

Original language	English
Pages (from-to)	10-15
Number of pages	6
Journal	Clinical Imaging
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.clinimag.2004.03.004
State	Published - Jan 2005

Bibliographical note

Funding Information:
This study was supported by a grant of the Center for Functional and Metabolic Imaging Technology, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV07-0002).

Keywords

Brain tumors
Gliomas
Magnetic resonance spectroscopy
Malignancy

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10.1016/j.clinimag.2004.03.004

Cite this

@article{c7b50a386dcd411aa673b2b941201820,

title = "Assessment of malignancy in gliomas by 3T 1H MR spectroscopy",

abstract = "The purpose of this study was to assess clinical 1H MR spectroscopy (MRS) as a noninvasive method for evaluating brain tumor malignancy at 3T high-field system. Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumor (i.e., gliomas) was employed to evaluate spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cr) and lactate. On the basis of Cr, these peak areas were quantitated as a relative ratio. The variation of metabolite measurements of the designated region in 10 normal volunteers was less than 10\%. Normal ranges of NAA/Cr and Cho/Cr ratios were 1.67±018 and 1.16±0.15, respectively. NAA/Cr ratio of gliomas was significantly lower than that of the normal tissues (P=.005), but Cho/Cr ratio of gliomas was significantly higher (P=.001). Cho/Cr ratio of high-grade gliomas was significantly higher than that of low-grade gliomas. The present study demonstrated that the neuronal degradation or loss was observed in all gliomas. Higher-grade glioma was correlated with higher Cho/Cr ratio, indicating a significant dependence of Cho levels on malignancy of gliomas. Our results suggest that clinical 1H MR spectroscopy could be useful to predict tumor malignancy.",

keywords = "Brain tumors, Gliomas, Magnetic resonance spectroscopy, Malignancy",

author = "Jeun, \{Sin Soo\} and Kim, \{Moon Chan\} and Kim, \{Bum Soo\} and Lee, \{Jae Mun\} and Chung, \{Sung Taek\} and Oh, \{Chang Hyun\} and Lee, \{Soo Yeol\} and Choe, \{Bo Young\}",

note = "Funding Information: This study was supported by a grant of the Center for Functional and Metabolic Imaging Technology, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV07-0002).",

year = "2005",

month = jan,

doi = "10.1016/j.clinimag.2004.03.004",

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journal = "Clinical Imaging",

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T1 - Assessment of malignancy in gliomas by 3T 1H MR spectroscopy

AU - Jeun, Sin Soo

AU - Kim, Moon Chan

AU - Kim, Bum Soo

AU - Lee, Jae Mun

AU - Chung, Sung Taek

AU - Oh, Chang Hyun

AU - Lee, Soo Yeol

AU - Choe, Bo Young

N1 - Funding Information: This study was supported by a grant of the Center for Functional and Metabolic Imaging Technology, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV07-0002).

PY - 2005/1

Y1 - 2005/1

N2 - The purpose of this study was to assess clinical 1H MR spectroscopy (MRS) as a noninvasive method for evaluating brain tumor malignancy at 3T high-field system. Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumor (i.e., gliomas) was employed to evaluate spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cr) and lactate. On the basis of Cr, these peak areas were quantitated as a relative ratio. The variation of metabolite measurements of the designated region in 10 normal volunteers was less than 10%. Normal ranges of NAA/Cr and Cho/Cr ratios were 1.67±018 and 1.16±0.15, respectively. NAA/Cr ratio of gliomas was significantly lower than that of the normal tissues (P=.005), but Cho/Cr ratio of gliomas was significantly higher (P=.001). Cho/Cr ratio of high-grade gliomas was significantly higher than that of low-grade gliomas. The present study demonstrated that the neuronal degradation or loss was observed in all gliomas. Higher-grade glioma was correlated with higher Cho/Cr ratio, indicating a significant dependence of Cho levels on malignancy of gliomas. Our results suggest that clinical 1H MR spectroscopy could be useful to predict tumor malignancy.

AB - The purpose of this study was to assess clinical 1H MR spectroscopy (MRS) as a noninvasive method for evaluating brain tumor malignancy at 3T high-field system. Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumor (i.e., gliomas) was employed to evaluate spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cr) and lactate. On the basis of Cr, these peak areas were quantitated as a relative ratio. The variation of metabolite measurements of the designated region in 10 normal volunteers was less than 10%. Normal ranges of NAA/Cr and Cho/Cr ratios were 1.67±018 and 1.16±0.15, respectively. NAA/Cr ratio of gliomas was significantly lower than that of the normal tissues (P=.005), but Cho/Cr ratio of gliomas was significantly higher (P=.001). Cho/Cr ratio of high-grade gliomas was significantly higher than that of low-grade gliomas. The present study demonstrated that the neuronal degradation or loss was observed in all gliomas. Higher-grade glioma was correlated with higher Cho/Cr ratio, indicating a significant dependence of Cho levels on malignancy of gliomas. Our results suggest that clinical 1H MR spectroscopy could be useful to predict tumor malignancy.

KW - Brain tumors

KW - Gliomas

KW - Magnetic resonance spectroscopy

KW - Malignancy

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