Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis

Yong Kyun Kim; Seok Joon Shin; Sang Hyun Ihm; Chan Seok Park; Hee Yeol Kim; Young Du Kim; Dong Suk Shim; Ho Cheol Song; Chul Woo Yang; Yong Soo Kim; Euy Jin Choi

doi:10.1007/s11255-009-9689-8

Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis

Yong Kyun Kim, Seok Joon Shin, Sang Hyun Ihm, Chan Seok Park, Hee Yeol Kim, Young Du Kim, Dong Suk Shim, Ho Cheol Song, Chul Woo Yang, Yong Soo Kim, Euy Jin Choi

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis. Methods This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay. Results During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan- Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NTproBNP above the median values compared to patients with lower concentrations (P = 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22-36.48, P = 0.029). Conclusions Our data suggest that plasma NTproBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.

Original language	English
Pages (from-to)	537-543
Number of pages	7
Journal	International Urology and Nephrology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1007/s11255-009-9689-8
State	Published - Jun 2010

Bibliographical note

Funding Information:
Acknowledgments The authors wish to acknowledge the financial support of the Clinical Medicine Research Institute Foundation of Holy Family Hospital, and this study was also supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A084001).

Keywords

Hemodialysis
Left ventricular fractional shortening
Left ventricular mass index
N-terminal pro-brain natriuretic peptide
Stroke

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11255-009-9689-8

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@article{3c8595635f6544358fa72c8e0be95957,

title = "Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis",

abstract = "Background Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis. Methods This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay. Results During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan- Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NTproBNP above the median values compared to patients with lower concentrations (P = 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22-36.48, P = 0.029). Conclusions Our data suggest that plasma NTproBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.",

keywords = "Hemodialysis, Left ventricular fractional shortening, Left ventricular mass index, N-terminal pro-brain natriuretic peptide, Stroke",

author = "Kim, {Yong Kyun} and Shin, {Seok Joon} and Ihm, {Sang Hyun} and Park, {Chan Seok} and Kim, {Hee Yeol} and Kim, {Young Du} and Shim, {Dong Suk} and Song, {Ho Cheol} and Yang, {Chul Woo} and Kim, {Yong Soo} and Choi, {Euy Jin}",

note = "Funding Information: Acknowledgments The authors wish to acknowledge the financial support of the Clinical Medicine Research Institute Foundation of Holy Family Hospital, and this study was also supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A084001).",

year = "2010",

month = jun,

doi = "10.1007/s11255-009-9689-8",

language = "English",

volume = "42",

pages = "537--543",

journal = "International Urology and Nephrology",

issn = "0301-1623",

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T1 - Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis

AU - Kim, Yong Kyun

AU - Shin, Seok Joon

AU - Ihm, Sang Hyun

AU - Park, Chan Seok

AU - Kim, Hee Yeol

AU - Kim, Young Du

AU - Shim, Dong Suk

AU - Song, Ho Cheol

AU - Yang, Chul Woo

AU - Kim, Yong Soo

AU - Choi, Euy Jin

N1 - Funding Information: Acknowledgments The authors wish to acknowledge the financial support of the Clinical Medicine Research Institute Foundation of Holy Family Hospital, and this study was also supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A084001).

PY - 2010/6

Y1 - 2010/6

N2 - Background Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis. Methods This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay. Results During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan- Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NTproBNP above the median values compared to patients with lower concentrations (P = 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22-36.48, P = 0.029). Conclusions Our data suggest that plasma NTproBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.

AB - Background Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis. Methods This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay. Results During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan- Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NTproBNP above the median values compared to patients with lower concentrations (P = 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22-36.48, P = 0.029). Conclusions Our data suggest that plasma NTproBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.

KW - Hemodialysis

KW - Left ventricular fractional shortening

KW - Left ventricular mass index

KW - N-terminal pro-brain natriuretic peptide

KW - Stroke

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SN - 0301-1623

VL - 42

SP - 537

EP - 543

JO - International Urology and Nephrology

JF - International Urology and Nephrology

IS - 2

ER -

Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis

Abstract

Bibliographical note

Keywords

UN SDGs

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