Associations of general and abdominal obesity with the risk of glioma development

Stephen Ahn; Kyungdo Han; Jung Eun Lee; Sin Soo Jeun; Yong Moon Park; Seung Ho Yang

doi:10.3390/cancers13122859

Associations of general and abdominal obesity with the risk of glioma development

Stephen Ahn, Kyungdo Han, Jung Eun Lee, Sin Soo Jeun, Yong Moon Park, Seung Ho Yang

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The association between obesity and the risk of glioma remains unclear. We sought to evaluate the potential association between general and abdominal obesity and the risk of glioma based on a nationwide population-based cohort study of Koreans. Using data from the Korean National Health Insurance System cohort, 6,833,744 people older than 20 years who underwent regular national health examination in both 2009 and 2011 were followed until the end of 2017. We documented 4771 glioma cases based on an ICD-10 code of C71 during the median follow-up period of 7.30 years. Individuals with a body mass index (BMI) ≥ 25.0 kg/m² were at significantly higher risk of developing glioma than those with a BMI < 25.0 kg/m² (HR 1.08 CI 1.02–1.15). Individuals with a waist circumference (WC) ≥ 90 cm (males)/85 cm (females) also had a significantly higher risk of glioma than those with a WC < 90 cm (males)/85 cm (females) (HR 1.16 CI 1.09–1.24). In the group with a BMI ≥ 25.0 kg/m², individuals with abdominal obesity were at significantly higher risk of developing glioma (HR 1.18 CI 1.09–1.27) than those without abdominal obesity. The role of abdominal obesity in this association was stronger in women than in men. To the best of our knowledge, this is the first demonstration that obese people may be at higher risk of glioma, especially centrally obese people from an Asian population with a BMI ≥ 25.0 kg/m² . Loss of visceral fat in people with abdominal obesity may reduce their risk of developing glioma.

Original language	English
Article number	2859
Journal	Cancers
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/cancers13122859
State	Published - 2 Jun 2021

Bibliographical note

Funding Information:
Funding: This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT of South Korea (NRF-2020M3A9E8024875), and by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2019R1F1A1041197). The funder had no role in the design of the study.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Abdominal obesity
Glioma
Obesity
Risk factors
Waist circumstance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers13122859

Cite this

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title = "Associations of general and abdominal obesity with the risk of glioma development",

abstract = "The association between obesity and the risk of glioma remains unclear. We sought to evaluate the potential association between general and abdominal obesity and the risk of glioma based on a nationwide population-based cohort study of Koreans. Using data from the Korean National Health Insurance System cohort, 6,833,744 people older than 20 years who underwent regular national health examination in both 2009 and 2011 were followed until the end of 2017. We documented 4771 glioma cases based on an ICD-10 code of C71 during the median follow-up period of 7.30 years. Individuals with a body mass index (BMI) ≥ 25.0 kg/m2 were at significantly higher risk of developing glioma than those with a BMI < 25.0 kg/m2 (HR 1.08 CI 1.02–1.15). Individuals with a waist circumference (WC) ≥ 90 cm (males)/85 cm (females) also had a significantly higher risk of glioma than those with a WC < 90 cm (males)/85 cm (females) (HR 1.16 CI 1.09–1.24). In the group with a BMI ≥ 25.0 kg/m2, individuals with abdominal obesity were at significantly higher risk of developing glioma (HR 1.18 CI 1.09–1.27) than those without abdominal obesity. The role of abdominal obesity in this association was stronger in women than in men. To the best of our knowledge, this is the first demonstration that obese people may be at higher risk of glioma, especially centrally obese people from an Asian population with a BMI ≥ 25.0 kg/m2 . Loss of visceral fat in people with abdominal obesity may reduce their risk of developing glioma.",

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author = "Stephen Ahn and Kyungdo Han and Lee, {Jung Eun} and Jeun, {Sin Soo} and Park, {Yong Moon} and Yang, {Seung Ho}",

note = "Funding Information: Funding: This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT of South Korea (NRF-2020M3A9E8024875), and by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2019R1F1A1041197). The funder had no role in the design of the study. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Yang, Seung Ho

N1 - Funding Information: Funding: This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT of South Korea (NRF-2020M3A9E8024875), and by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2019R1F1A1041197). The funder had no role in the design of the study. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - The association between obesity and the risk of glioma remains unclear. We sought to evaluate the potential association between general and abdominal obesity and the risk of glioma based on a nationwide population-based cohort study of Koreans. Using data from the Korean National Health Insurance System cohort, 6,833,744 people older than 20 years who underwent regular national health examination in both 2009 and 2011 were followed until the end of 2017. We documented 4771 glioma cases based on an ICD-10 code of C71 during the median follow-up period of 7.30 years. Individuals with a body mass index (BMI) ≥ 25.0 kg/m2 were at significantly higher risk of developing glioma than those with a BMI < 25.0 kg/m2 (HR 1.08 CI 1.02–1.15). Individuals with a waist circumference (WC) ≥ 90 cm (males)/85 cm (females) also had a significantly higher risk of glioma than those with a WC < 90 cm (males)/85 cm (females) (HR 1.16 CI 1.09–1.24). In the group with a BMI ≥ 25.0 kg/m2, individuals with abdominal obesity were at significantly higher risk of developing glioma (HR 1.18 CI 1.09–1.27) than those without abdominal obesity. The role of abdominal obesity in this association was stronger in women than in men. To the best of our knowledge, this is the first demonstration that obese people may be at higher risk of glioma, especially centrally obese people from an Asian population with a BMI ≥ 25.0 kg/m2 . Loss of visceral fat in people with abdominal obesity may reduce their risk of developing glioma.

AB - The association between obesity and the risk of glioma remains unclear. We sought to evaluate the potential association between general and abdominal obesity and the risk of glioma based on a nationwide population-based cohort study of Koreans. Using data from the Korean National Health Insurance System cohort, 6,833,744 people older than 20 years who underwent regular national health examination in both 2009 and 2011 were followed until the end of 2017. We documented 4771 glioma cases based on an ICD-10 code of C71 during the median follow-up period of 7.30 years. Individuals with a body mass index (BMI) ≥ 25.0 kg/m2 were at significantly higher risk of developing glioma than those with a BMI < 25.0 kg/m2 (HR 1.08 CI 1.02–1.15). Individuals with a waist circumference (WC) ≥ 90 cm (males)/85 cm (females) also had a significantly higher risk of glioma than those with a WC < 90 cm (males)/85 cm (females) (HR 1.16 CI 1.09–1.24). In the group with a BMI ≥ 25.0 kg/m2, individuals with abdominal obesity were at significantly higher risk of developing glioma (HR 1.18 CI 1.09–1.27) than those without abdominal obesity. The role of abdominal obesity in this association was stronger in women than in men. To the best of our knowledge, this is the first demonstration that obese people may be at higher risk of glioma, especially centrally obese people from an Asian population with a BMI ≥ 25.0 kg/m2 . Loss of visceral fat in people with abdominal obesity may reduce their risk of developing glioma.

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KW - Risk factors

KW - Waist circumstance

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DO - 10.3390/cancers13122859

M3 - Article

AN - SCOPUS:85107330629

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 12

M1 - 2859

ER -

Associations of general and abdominal obesity with the risk of glioma development

Abstract

Bibliographical note

Keywords

UN SDGs

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