Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

Sung Woo Huh; Asode Ananthram Shetty; Jang Mook Kim; Mi La Cho; Seon Ae Kim; Siyoung Yang; Young Ju Kim; Palaksha Kanive Javaregowda; Nam Yong Choi; Jin Kang; Seok Jung Kim

doi:10.1007/s13770-016-9125-y

Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

Sung Woo Huh
, Asode Ananthram Shetty
, Jang Mook Kim
, Mi La Cho
, Seon Ae Kim
, Siyoung Yang
, Young Ju Kim
, Palaksha Kanive Javaregowda
, Nam Yong Choi
, Jin Kang
, Seok Jung Kim

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients’ satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.

Original language	English
Pages (from-to)	200-209
Number of pages	10
Journal	Tissue Engineering and Regenerative Medicine
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/s13770-016-9125-y
State	Published - 1 Apr 2016

Bibliographical note

Publisher Copyright:
© 2016, The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media Dordrecht.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chondrogenesis
Economy
Mesenchymal cell induced chondrogenesis
Osteoarthritis
Total knee arthroplasty

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10.1007/s13770-016-9125-y

Cite this

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title = "Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee",

abstract = "Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients{\textquoteright} satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.",

keywords = "Chondrogenesis, Economy, Mesenchymal cell induced chondrogenesis, Osteoarthritis, Total knee arthroplasty",

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doi = "10.1007/s13770-016-9125-y",

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T1 - Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

AU - Huh, Sung Woo

AU - Shetty, Asode Ananthram

AU - Kim, Jang Mook

AU - Cho, Mi La

AU - Kim, Seon Ae

AU - Yang, Siyoung

AU - Kim, Young Ju

AU - Javaregowda, Palaksha Kanive

AU - Choi, Nam Yong

AU - Kang, Jin

AU - Kim, Seok Jung

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients’ satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.

AB - Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients’ satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.

KW - Chondrogenesis

KW - Economy

KW - Mesenchymal cell induced chondrogenesis

KW - Osteoarthritis

KW - Total knee arthroplasty

UR - https://www.scopus.com/pages/publications/84962449617

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DO - 10.1007/s13770-016-9125-y

M3 - Article

AN - SCOPUS:84962449617

SN - 1738-2696

VL - 13

SP - 200

EP - 209

JO - Tissue Engineering and Regenerative Medicine

JF - Tissue Engineering and Regenerative Medicine

IS - 2

ER -

Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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