TY - JOUR
T1 - Behcet's disease associated with myelodysplastic syndrome
T2 - A case report
AU - Oh, Eun Jee
AU - Yoon, Jeong Sook
AU - Park, Yeon Joon
AU - Cho, Cheol Soo
AU - Kim, Byung Kee
PY - 1999/12
Y1 - 1999/12
N2 - A rare case of Behcet's disease associated with myelodysplastic syndrome (MDS) is described. A 50-year-old Korean female suffering recurrent oral ulcer, genital ulcer, fatigue, arthralgia in both knees and fever was diagnosed as Behcet's disease. The findings of bone marrow aspirates were consistent with refractory anemia, a subtype of myelodysplastic syndrome. Chromosomal analysis of bone marrow cells revealed 46,XX,-8,-20,+der(8)t(8;20)(p23;p10),+der(8) t(8;20)(p23;q10)[30]. The chromosomal changes found in this patient were different from those of previous reports, which mostly revealed trisomy 8. If anemia, low reticulocyte count and dyspoietic cells are sustained in Behcet's disease, physicians should be alert to the possibility of MDS with aberration in chromosome 8 and perform a bone marrow study for the proper diagnosis and treatment of the disease. We presented a case of Behcet's disease associated with MDS, which is the first Korean case.
AB - A rare case of Behcet's disease associated with myelodysplastic syndrome (MDS) is described. A 50-year-old Korean female suffering recurrent oral ulcer, genital ulcer, fatigue, arthralgia in both knees and fever was diagnosed as Behcet's disease. The findings of bone marrow aspirates were consistent with refractory anemia, a subtype of myelodysplastic syndrome. Chromosomal analysis of bone marrow cells revealed 46,XX,-8,-20,+der(8)t(8;20)(p23;p10),+der(8) t(8;20)(p23;q10)[30]. The chromosomal changes found in this patient were different from those of previous reports, which mostly revealed trisomy 8. If anemia, low reticulocyte count and dyspoietic cells are sustained in Behcet's disease, physicians should be alert to the possibility of MDS with aberration in chromosome 8 and perform a bone marrow study for the proper diagnosis and treatment of the disease. We presented a case of Behcet's disease associated with MDS, which is the first Korean case.
KW - Behcet's syndrome
KW - Chromosomes, human, pair 8
KW - Myelodysplastic syndromes
KW - Translocation (genetics)
UR - https://www.scopus.com/pages/publications/0033250941
U2 - 10.3346/jkms.1999.14.6.685
DO - 10.3346/jkms.1999.14.6.685
M3 - Article
C2 - 10642951
AN - SCOPUS:0033250941
SN - 1011-8934
VL - 14
SP - 685
EP - 687
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
IS - 6
ER -
