TY - JOUR
T1 - Beneficial effects of prostglandin on rat cardiac allografts with cyclosporine immunosuppression
AU - Koh, Y. B.
AU - Moon, I. S.
AU - Park, S. C.
PY - 2005
Y1 - 2005
N2 - Graft rejection is characterized by cellular infiltration, reduction in blood flow, and intravascular coagulation, finally resulting in graft failure and absolute increase in thromboxane and relative decrease in prostacyclin synthesis. It is also suspected that prostaglandin itself could cause prolongation of allograft survival. In this experimental study, after successful heterotopic cardiac transplantation in rats, CyA was administered by intramuscular injection and prostaglandin E1 (PGE1) given into the peritoneal cavity. Each dose was according to the experimental designs. The authors found that PGE1 in addition to CyA could provide beneficial effects with significantly increased cardiac allograft survival, with amelioration of pathological changes in allograft rejection reaction.
AB - Graft rejection is characterized by cellular infiltration, reduction in blood flow, and intravascular coagulation, finally resulting in graft failure and absolute increase in thromboxane and relative decrease in prostacyclin synthesis. It is also suspected that prostaglandin itself could cause prolongation of allograft survival. In this experimental study, after successful heterotopic cardiac transplantation in rats, CyA was administered by intramuscular injection and prostaglandin E1 (PGE1) given into the peritoneal cavity. Each dose was according to the experimental designs. The authors found that PGE1 in addition to CyA could provide beneficial effects with significantly increased cardiac allograft survival, with amelioration of pathological changes in allograft rejection reaction.
UR - https://www.scopus.com/pages/publications/16244377130
U2 - 10.1016/j.transproceed.2005.01.062
DO - 10.1016/j.transproceed.2005.01.062
M3 - Article
C2 - 15808573
AN - SCOPUS:16244377130
SN - 0041-1345
VL - 37
SP - 137
EP - 138
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 1
ER -