Abstract
C-kit-negative gastrointestinal stromal tumors (GISTs) are uncommon, and there have been few reports about the diagnosis and treatment of c-kit-negative GISTs in the stomach. We report the case of a patient who was diagnosed with a huge and atypical GIST in the stomach. The GIST was completely resected and finally diagnosed as c-kit-negative GIST based on immunohistochemical staining of tumor cells, which were negative for CD117 and CD34 and positive for Discovered on GIST-1 (DOG1). C-kit-negative GISTs could be treated by complete resection and/or imatinib, which is the same treatment for c-kit-positive GISTs.
| Original language | English |
|---|---|
| Pages (from-to) | 290-294 |
| Number of pages | 5 |
| Journal | Journal of Gastric Cancer |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2015 |
Bibliographical note
Publisher Copyright:© 2015 by The Korean Gastric Cancer Association.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- C-kit protein
- DOG1 protein
- Gastrointestinal stromal tumors
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