Calsequestrin: a well-known but curious protein in skeletal muscle

Jin Seok Woo; Seung Yeon Jeong; Ji Hee Park; Jun Hee Choi; Eun Hui Lee

doi:10.1038/s12276-020-00535-1

Calsequestrin: a well-known but curious protein in skeletal muscle

Jin Seok Woo
, Seung Yeon Jeong
, Ji Hee Park
, Jun Hee Choi
, Eun Hui Lee

Department of Physiology

University of California at Los Angeles
The Catholic University of Korea

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Calsequestrin (CASQ) was discovered in rabbit skeletal muscle tissues in 1971 and has been considered simply a passive Ca²⁺-buffering protein in the sarcoplasmic reticulum (SR) that provides Ca²⁺ ions for various Ca²⁺ signals. For the past three decades, physiologists, biochemists, and structural biologists have examined the roles of the skeletal muscle type of CASQ (CASQ1) in skeletal muscle and revealed that CASQ1 has various important functions as (1) a major Ca²⁺-buffering protein to maintain the SR with a suitable amount of Ca²⁺ at each moment, (2) a dynamic Ca²⁺ sensor in the SR that regulates Ca²⁺ release from the SR to the cytosol, (3) a structural regulator for the proper formation of terminal cisternae, (4) a reverse-directional regulator of extracellular Ca²⁺ entries, and (5) a cause of human skeletal muscle diseases. This review is focused on understanding these functions of CASQ1 in the physiological or pathophysiological status of skeletal muscle.

Original language	English
Pages (from-to)	1908-1925
Number of pages	18
Journal	Experimental and Molecular Medicine
Volume	52
Issue number	12
DOIs	https://doi.org/10.1038/s12276-020-00535-1
State	Published - Dec 2020

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Publisher Copyright:
© 2020, The Author(s).

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title = "Calsequestrin: a well-known but curious protein in skeletal muscle",

abstract = "Calsequestrin (CASQ) was discovered in rabbit skeletal muscle tissues in 1971 and has been considered simply a passive Ca2+-buffering protein in the sarcoplasmic reticulum (SR) that provides Ca2+ ions for various Ca2+ signals. For the past three decades, physiologists, biochemists, and structural biologists have examined the roles of the skeletal muscle type of CASQ (CASQ1) in skeletal muscle and revealed that CASQ1 has various important functions as (1) a major Ca2+-buffering protein to maintain the SR with a suitable amount of Ca2+ at each moment, (2) a dynamic Ca2+ sensor in the SR that regulates Ca2+ release from the SR to the cytosol, (3) a structural regulator for the proper formation of terminal cisternae, (4) a reverse-directional regulator of extracellular Ca2+ entries, and (5) a cause of human skeletal muscle diseases. This review is focused on understanding these functions of CASQ1 in the physiological or pathophysiological status of skeletal muscle.",

author = "Woo, \{Jin Seok\} and Jeong, \{Seung Yeon\} and Park, \{Ji Hee\} and Choi, \{Jun Hee\} and Lee, \{Eun Hui\}",

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month = dec,

doi = "10.1038/s12276-020-00535-1",

language = "English",

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T2 - a well-known but curious protein in skeletal muscle

AU - Woo, Jin Seok

AU - Jeong, Seung Yeon

AU - Park, Ji Hee

AU - Choi, Jun Hee

AU - Lee, Eun Hui

PY - 2020/12

Y1 - 2020/12

N2 - Calsequestrin (CASQ) was discovered in rabbit skeletal muscle tissues in 1971 and has been considered simply a passive Ca2+-buffering protein in the sarcoplasmic reticulum (SR) that provides Ca2+ ions for various Ca2+ signals. For the past three decades, physiologists, biochemists, and structural biologists have examined the roles of the skeletal muscle type of CASQ (CASQ1) in skeletal muscle and revealed that CASQ1 has various important functions as (1) a major Ca2+-buffering protein to maintain the SR with a suitable amount of Ca2+ at each moment, (2) a dynamic Ca2+ sensor in the SR that regulates Ca2+ release from the SR to the cytosol, (3) a structural regulator for the proper formation of terminal cisternae, (4) a reverse-directional regulator of extracellular Ca2+ entries, and (5) a cause of human skeletal muscle diseases. This review is focused on understanding these functions of CASQ1 in the physiological or pathophysiological status of skeletal muscle.

AB - Calsequestrin (CASQ) was discovered in rabbit skeletal muscle tissues in 1971 and has been considered simply a passive Ca2+-buffering protein in the sarcoplasmic reticulum (SR) that provides Ca2+ ions for various Ca2+ signals. For the past three decades, physiologists, biochemists, and structural biologists have examined the roles of the skeletal muscle type of CASQ (CASQ1) in skeletal muscle and revealed that CASQ1 has various important functions as (1) a major Ca2+-buffering protein to maintain the SR with a suitable amount of Ca2+ at each moment, (2) a dynamic Ca2+ sensor in the SR that regulates Ca2+ release from the SR to the cytosol, (3) a structural regulator for the proper formation of terminal cisternae, (4) a reverse-directional regulator of extracellular Ca2+ entries, and (5) a cause of human skeletal muscle diseases. This review is focused on understanding these functions of CASQ1 in the physiological or pathophysiological status of skeletal muscle.

UR - https://www.scopus.com/pages/publications/85097230596

U2 - 10.1038/s12276-020-00535-1

DO - 10.1038/s12276-020-00535-1

M3 - Review article

C2 - 33288873

AN - SCOPUS:85097230596

SN - 1226-3613

VL - 52

SP - 1908

EP - 1925

JO - Experimental and Molecular Medicine

JF - Experimental and Molecular Medicine

IS - 12

ER -

Calsequestrin: a well-known but curious protein in skeletal muscle

Abstract

Bibliographical note

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