TY - JOUR
T1 - Cancer risk in patients with Behçet disease
T2 - A nationwide population-based dynamic cohort study from Korea
AU - Na, Sae Jung
AU - Kang, Min Ji
AU - Yu, Dong Soo
AU - Han, Kyung Do
AU - Lee, Ji Hyun
AU - Park, Yong Gyu
AU - Lee, Young Bok
N1 - Publisher Copyright:
© 2017 American Academy of Dermatology, Inc.
PY - 2018/3
Y1 - 2018/3
N2 - Background: Many studies have shown a link between inflammation and cancer development. However, there are few studies regarding the correlation between Behçet disease (BD) and cancer. Objectives: To determine the overall cancer risk and risk for specific cancers in patients with BD. Methods: Patients with BD (n = 14,137; mean age, 44.2 ± 12.5 years; male patients, 32.4%) without known previous cancer were selected from the Korean National Health Insurance Database between 2007 and 2014. An age- and sex-matched control population of individuals without BD was randomly sampled at a ratio of 10:1. Both cohorts were followed for incident cancer until 2015. Results: Overall, cancer was newly diagnosed in 451 patients with BD (3.19%) and 3975 controls (2.81%) during the follow-up period. Patients with BD showed a significantly higher risk for cancer compared with the controls (hazard ratio [HR], 1.134; 95% confidence interval [CI], 1.029-1.25), leukemia (HR, 5.801; 95% CI, 3.24-10.385), lymphoma (HR, 2.584; 95% CI, 1.559-4.283), oral cavity and pharyngeal cancer (HR, 2.113; 95% CI, 1.102-4.052), thyroid cancer (HR, 1.256; 95% CI, 1.05-1.501), and prostate cancer (HR, 1.784; 95% CI, 1.141-2.791). Limitations: The treatment or severity of diseases in each individual was not examined. Conclusions: Patients with BD had a higher risk for overall cancer compared with controls without BD. Physicians should carefully monitor patients with BD for the potential development of malignancies.
AB - Background: Many studies have shown a link between inflammation and cancer development. However, there are few studies regarding the correlation between Behçet disease (BD) and cancer. Objectives: To determine the overall cancer risk and risk for specific cancers in patients with BD. Methods: Patients with BD (n = 14,137; mean age, 44.2 ± 12.5 years; male patients, 32.4%) without known previous cancer were selected from the Korean National Health Insurance Database between 2007 and 2014. An age- and sex-matched control population of individuals without BD was randomly sampled at a ratio of 10:1. Both cohorts were followed for incident cancer until 2015. Results: Overall, cancer was newly diagnosed in 451 patients with BD (3.19%) and 3975 controls (2.81%) during the follow-up period. Patients with BD showed a significantly higher risk for cancer compared with the controls (hazard ratio [HR], 1.134; 95% confidence interval [CI], 1.029-1.25), leukemia (HR, 5.801; 95% CI, 3.24-10.385), lymphoma (HR, 2.584; 95% CI, 1.559-4.283), oral cavity and pharyngeal cancer (HR, 2.113; 95% CI, 1.102-4.052), thyroid cancer (HR, 1.256; 95% CI, 1.05-1.501), and prostate cancer (HR, 1.784; 95% CI, 1.141-2.791). Limitations: The treatment or severity of diseases in each individual was not examined. Conclusions: Patients with BD had a higher risk for overall cancer compared with controls without BD. Physicians should carefully monitor patients with BD for the potential development of malignancies.
KW - Behçet disease
KW - cancer
KW - hazard ratio
KW - incidence
UR - http://www.scopus.com/inward/record.url?scp=85033687151&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2017.09.035
DO - 10.1016/j.jaad.2017.09.035
M3 - Article
C2 - 28958833
AN - SCOPUS:85033687151
SN - 0190-9622
VL - 78
SP - 464-470.e2
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -
