Abstract
Advances in the understanding of central nervous system aquarporin-4 autoimmunity have promoted the recognition of diverse clinical presentations beyond the traditional view of neuromyelitis optica. We describe a patient who developed hemiparesis caused by an extensive cerebral lesion as an initial manifestation of central nervous system aquarporin-4 autoimmunity. Although the patient had no history of optic neuritis or myelitis, not only was serum anti-aquarporin-4 antibody positive, but an imaging, treatment response and histopathological features also revealed characteristic findings suggestive of central nervous system aquarporin-4 autoimmunity. The present case highlights the importance of a comprehensive evaluation for anti-aquarporin-4 antibody even in patients presenting with isolated cerebral lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 1340-1343 |
| Number of pages | 4 |
| Journal | Multiple Sclerosis Journal |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2012 |
Bibliographical note
Funding Information:Dr Kim HJ has received a research grant from the Ministry for Health, Welfare and Family Affairs and honoraria for speaking or consulting from Bayer Schering Pharma, Merck Serono, and Novartis.
Funding Information:
The measurement of anti-aquaporin-4 antibody in this study was supported by grant A080588–28 from the Korea Healthcare Technology and Research and Development Project, Ministry of Health, Welfare, and Family Affairs, Republic or Korea (Dr Kim HJ).
Keywords
- Aquaporin-4
- neuromyelitis optica
- neuromyelitis optica spectrum disorder
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