Abstract
Magneto-fluorescent silica nanoparticles were conjugated with cetuximab for the targeting and imaging of colon cancer. In this study, cetuximab-conjugated magneto-fluorescent nanoparticles (MFSN-Ctx) could specifically target colon cancer cells that expressed EGFR on their cell membranes, and specific fluorescence was detected. MFSN-Ctx produced significant MRI signal changes in a human colon cancer xenograft mouse model. Intravenous injection of MFSN-Ctx resulted in faster uptake as compared to intraperitoneal injection, indicating that MFSN-Ctx had different kinetic properties in tumors based on the method of injection. The local concentration of MFSN-Ctx in a tumor was amplified by the use of an external magnetic field. These results demonstrate the potential application of MFSN-Ctx for the detection of EGFR-expressing colon cancer using in vivo imaging approaches.
| Original language | English |
|---|---|
| Pages (from-to) | 63-71 |
| Number of pages | 9 |
| Journal | Cancer Letters |
| Volume | 299 |
| Issue number | 1 |
| DOIs | |
| State | Published - 18 Dec 2010 |
Bibliographical note
Funding Information:This work was supported by a Korea Research Foundation to Eue-Soon Jang, a Korea Research Foundation Grant (KRF-2006-352-C00037) to Tae-Jong Yoon and a Korea Basic Science Institute Grant (T 27041) to Kwan Soo Hong.
Keywords
- Cetuximab
- Colon cancer
- Molecular imaging
- Nanoparticles
