Abstract
Purpose: To evaluate the changes in intraocular cytokine after intravitreal bevacizumab (IVB) for uveiticcystoid macular edema (CME). Methods: The authors evaluated 9 eyes of 8 patients who underwent IVB for uveitic CME. The aqueous humorlevels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β2were measured using suspension array technology at baseline and 1 month after IVB. Results: The VEGF level was decreased to insignificant level (p=.008). TGF-β2 and TNF-α levels increased significantly (p=.008 and .021, respectively). IL-6 and IL-8 showed no significant change (p=.051 and.110, respectively). Conclusion: IVB resulted in a significant decrease of VEGF levels, which was associated with anatomical improvement of CME at 1 month. Compensatory elevations of proinflammatory cytokines (IL-6 and IL-8) after selective VEGF inhibition were not observed. Marked elevation of TGF-β2 after IVB seems to play an immunosuppressive role.
| Original language | English |
|---|---|
| Pages (from-to) | 360-364 |
| Number of pages | 5 |
| Journal | Ocular Immunology and Inflammation |
| Volume | 20 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 2012 |
Keywords
- Interleukin-6
- Interleukin-8
- Transforming growth factor -β2
- Tumor necrosis factor -α
- Uveitic macular edema
- Vascular endothelial growth factor
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