TY - JOUR
T1 - Changes in the tear film and ocular surface after cataract surgery
AU - Oh, Taehoon
AU - Jung, Younhea
AU - Chang, Dongjin
AU - Kim, Jaeryun
AU - Kim, Hyunseung
PY - 2012/3
Y1 - 2012/3
N2 - Purpose: To evaluate changes in corneal sensitivity, tear film function, and ocular surface stability in patients after cataract surgery. Methods: This hospital-based prospective randomized trial included 48 eyes from 30 patients who underwent phacoemulsification. Slit-lamp examination, Schirmer test 1 (ST1), and measurement of corneal sensitivity and tear film breakup time (BUT) were performed for all patients 1 day before and 1 day, 1 month, and 3 months after surgery. In addition, conjunctival impression cytology from the temporal region of the conjunctiva was simultaneously performed. Results: Corneal sensitivity at the center and temporal incision sites had decreased significantly at 1 day postoperatively (P = .021, P < .001). However, the sensitivity had returned to almost the preoperative level 1 month postoperatively. The mean postoperative ST1 results were no different from preoperative values. On the other hand, BUT results had decreased significantly at 1 day postoperatively (P = .01) but had returned to almost the preoperative level 1 month postoperatively. Mean goblet cell density (GCD) had decreased significantly at 1 day, 1 month, and 3 months postoperatively (P < .001). In addition, decrease in GCD and cataract operative time were highly correlated (r2 = 0.65). Conclusions: The decrease in GCD, which was correlated with operative time, had not recovered at 3 months after cataract surgery. Therefore, microscopic ocular surface damage during cataract surgery seems to be one of the pathogenic factors that cause ocular discomfort and dry eye syndrome after cataract surgery.
AB - Purpose: To evaluate changes in corneal sensitivity, tear film function, and ocular surface stability in patients after cataract surgery. Methods: This hospital-based prospective randomized trial included 48 eyes from 30 patients who underwent phacoemulsification. Slit-lamp examination, Schirmer test 1 (ST1), and measurement of corneal sensitivity and tear film breakup time (BUT) were performed for all patients 1 day before and 1 day, 1 month, and 3 months after surgery. In addition, conjunctival impression cytology from the temporal region of the conjunctiva was simultaneously performed. Results: Corneal sensitivity at the center and temporal incision sites had decreased significantly at 1 day postoperatively (P = .021, P < .001). However, the sensitivity had returned to almost the preoperative level 1 month postoperatively. The mean postoperative ST1 results were no different from preoperative values. On the other hand, BUT results had decreased significantly at 1 day postoperatively (P = .01) but had returned to almost the preoperative level 1 month postoperatively. Mean goblet cell density (GCD) had decreased significantly at 1 day, 1 month, and 3 months postoperatively (P < .001). In addition, decrease in GCD and cataract operative time were highly correlated (r2 = 0.65). Conclusions: The decrease in GCD, which was correlated with operative time, had not recovered at 3 months after cataract surgery. Therefore, microscopic ocular surface damage during cataract surgery seems to be one of the pathogenic factors that cause ocular discomfort and dry eye syndrome after cataract surgery.
KW - Cataract surgery
KW - Dry eye syndrome
KW - Goblet cell loss
KW - Impression cytology
UR - http://www.scopus.com/inward/record.url?scp=84862819687&partnerID=8YFLogxK
U2 - 10.1007/s10384-012-0117-8
DO - 10.1007/s10384-012-0117-8
M3 - Article
C2 - 22298313
AN - SCOPUS:84862819687
SN - 0021-5155
VL - 56
SP - 113
EP - 118
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
IS - 2
ER -