TY - JOUR
T1 - Clinical characteristics and survival of 413 patients with systemic lupus erythematosus in southeastern areas of South Korea
T2 - A multicenter retrospective cohort study
AU - Koh, Jung Hee
AU - Park, Eun Kyoung
AU - Lee, Han Na
AU - Kim, Yunkyung
AU - Kim, Geun Tae
AU - Suh, Young Sun
AU - Kim, Hyun Ok
AU - Lee, Seung Geun
N1 - Publisher Copyright:
© 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Aims: To investigate demographic, clinical, laboratory, and immunological characteristics of patients with systemic lupus erythematosus (SLE) in southeastern areas of South Korea, and to perform survival analysis. Methods: We retrospectively evaluated 413 patients with SLE diagnosed in 3 tertiary rheumatology centers in South Korea from 1992 to 2016 by reviewing their medical charts. All patients fulfilled the 1997 revised American College of Rheumatology classification criteria for SLE. Results: Most patients were women (92%), and the mean (±standard deviation) age at diagnosis was 30.9 (±12.9) years. The most common clinical manifestation was leukopenia (74.3%), followed by lymphopenia (73.6%), arthritis (59.1%), malar rash (48.4%), thrombocytopenia (46.5%), oral ulcer (35.1%), and biopsy-proven lupus nephritis (31.2%). Anti-nuclear, anti-double-stranded DNA, anti-Smith, and anti-Ro antibodies were positive in 97.8%, 70.1%, 38.4%, and 63% of patients, respectively. Twenty (4.8%) patients died during a median follow-up of 83 months, and the cumulative 5-year and 10-year survival rates were 96.9% and 95.5%, respectively. The major causes of death were infection (50%) and lupus flare-up (50%). Male (hazards ratio [HR] = 7.19, P =.001), pleuritis and/or pericarditis (HR = 3.28, P =.012), childhood-onset (HR = 3.57, P =.012), and late-onset (HR = 4.65, P =.011) were independent risk factors for death. Compared with SLE cohorts in other ethnicities or countries, our patients tended to have a higher frequency of anti-Ro antibodies and hematologic disorders. Conclusion: This study describes clinical features of SLE in South Korea and suggests a remarkable phenotypic heterogeneity of SLE.
AB - Aims: To investigate demographic, clinical, laboratory, and immunological characteristics of patients with systemic lupus erythematosus (SLE) in southeastern areas of South Korea, and to perform survival analysis. Methods: We retrospectively evaluated 413 patients with SLE diagnosed in 3 tertiary rheumatology centers in South Korea from 1992 to 2016 by reviewing their medical charts. All patients fulfilled the 1997 revised American College of Rheumatology classification criteria for SLE. Results: Most patients were women (92%), and the mean (±standard deviation) age at diagnosis was 30.9 (±12.9) years. The most common clinical manifestation was leukopenia (74.3%), followed by lymphopenia (73.6%), arthritis (59.1%), malar rash (48.4%), thrombocytopenia (46.5%), oral ulcer (35.1%), and biopsy-proven lupus nephritis (31.2%). Anti-nuclear, anti-double-stranded DNA, anti-Smith, and anti-Ro antibodies were positive in 97.8%, 70.1%, 38.4%, and 63% of patients, respectively. Twenty (4.8%) patients died during a median follow-up of 83 months, and the cumulative 5-year and 10-year survival rates were 96.9% and 95.5%, respectively. The major causes of death were infection (50%) and lupus flare-up (50%). Male (hazards ratio [HR] = 7.19, P =.001), pleuritis and/or pericarditis (HR = 3.28, P =.012), childhood-onset (HR = 3.57, P =.012), and late-onset (HR = 4.65, P =.011) were independent risk factors for death. Compared with SLE cohorts in other ethnicities or countries, our patients tended to have a higher frequency of anti-Ro antibodies and hematologic disorders. Conclusion: This study describes clinical features of SLE in South Korea and suggests a remarkable phenotypic heterogeneity of SLE.
KW - Republic Korea
KW - epidemiology
KW - ethnic groups
KW - mortality
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85076085217&partnerID=8YFLogxK
U2 - 10.1111/1756-185X.13761
DO - 10.1111/1756-185X.13761
M3 - Article
C2 - 31802639
AN - SCOPUS:85076085217
SN - 1756-1841
VL - 23
SP - 92
EP - 100
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
IS - 1
ER -