Clinical Clues to Predict the Presence of Parafoveal Scotoma on Humphrey 10-2 Visual Field Using a Humphrey 24-2 Visual Field

Purpose To investigate characteristics related to the presence of parafoveal scotoma on Humphrey 10-2 visual field (VF) in early glaucoma patients. Design Prospective, cross-sectional study. Methods participants: Ninety-one eyes from 91 patients with glaucomatous optic neuropathy were prospectively tested with a 10-2 VF test. observation procedures: Glaucoma patients were classified into eyes with or without parafoveal scotoma on 10-2 VF based on pattern deviation plot. The central 10 degree region of Humphrey 24-2 VF test comprised 12 points and any abnormal VF points depressed <5%, <2%, <1%, or <0.5% from the normal database on pattern deviation plot were analyzed. Various factors related to the presence of parafoveal scotoma on 10-2 VF were analyzed. main outcome measures: Abnormal 24-2 VF points, macular ganglion cell-inner plexiform layer thickness. Results The presence of abnormal 24-2 VF points <0.5% was significantly different between eyes with and without parafoveal scotoma on 10-2 VF (P <.01). The minimum macular ganglion cell-inner plexiform layer thickness (P =.04), any central 12 points depressed <0.5% on 24-2 VF (P <.01), and any central 12 points depressed <5% on 24-2 VF that spatially corresponds to macular ganglion cell-inner plexiform layer thinning (P < 0.01) were related factors to the presence of parafoveal scotoma on 10-2 VF. Conclusions Glaucomatous eyes with any abnormal 24-2 VF points on the central 10 degree region that are depressed <0.5% or <5% that correlates to macular ganglion cell-inner plexiform layer thinning should receive attention and be further evaluated with a 10-2 VF test.