TY - JOUR
T1 - Clinical, histopathological, and molecular characteristics of papillary thyroid microcarcinoma
AU - Lim, Dong Jun
AU - Baek, Ki Hyun
AU - Lee, Youn Soo
AU - Park, Woo Chan
AU - Kim, Mee Kyoung
AU - Kang, Moo Il
AU - Jeon, Hae Myung
AU - Lee, Jong Min
AU - Bong, Yun Cha
AU - Lee, Kwang Woo
AU - Son, Ho Young
AU - Kang, Sung Koo
PY - 2007/9
Y1 - 2007/9
N2 - Background: Papillary thyroid microcarcinoma (PTMC) detection has been increasing explosively with the recent improvement and application of new diagnostic tools. However, the associations between clinical, histopathological, and molecular findings are often not fully evaluated in reaching a decision for the treatment of PTMC. Objective: To retrospectively evaluate the patients diagnosed with PTMC in terms of the clinical and histopathological features and the immunohistochemical findings of specific molecular markers, and thereby provide an association with the disease prognosis for the Korean patients. Design: We have reviewed the clinical records of patients who underwent surgery for thyroid cancer (during January 2000 to August 2006 interval) at St. Mary's Hospital, Seoul, Korea. The clinical and histopathological characteristics of 217 PTMCs were evaluated cross-sectionally after surgery, and immunohistochemical staining of p53, epidermal growth factor receptor (EGFR), Ki-67, and cyclooxygenase-2 (COX-2) for 87 isolated specimens was performed. Main outcome: The proportions of extrathyroid extension, lymphatic invasion, and lymph node metastasis cited were 31.9%, 19.2%, and 17.8%, respectively. However, distant metastasis was not noted. Fifty-three (27.1%) patients had multiplicity, and 39 patients (20.0%) had bilateral disease. A primary tumor larger than 5 mm was significantly associated with extrathyroid extension, lymphatic invasion, and lymph node metastasis. The absence of EGFR expression shown by immunohistochemical analysis was closely correlated with extrathyroid extension and lymph node metastasis, while the absence of COX-2 expression was associated with multiplicity and bilaterality. Conclusion: Many patients with PTMC had clinical and histopathological poor prognostic factors. The expression of molecular markers, such as EGFR and COX-2, may have a role in the prognosis of PTMC. When considering all of the prognostic factors, a more tailored management approach appears to be necessary for patients with PTMC.
AB - Background: Papillary thyroid microcarcinoma (PTMC) detection has been increasing explosively with the recent improvement and application of new diagnostic tools. However, the associations between clinical, histopathological, and molecular findings are often not fully evaluated in reaching a decision for the treatment of PTMC. Objective: To retrospectively evaluate the patients diagnosed with PTMC in terms of the clinical and histopathological features and the immunohistochemical findings of specific molecular markers, and thereby provide an association with the disease prognosis for the Korean patients. Design: We have reviewed the clinical records of patients who underwent surgery for thyroid cancer (during January 2000 to August 2006 interval) at St. Mary's Hospital, Seoul, Korea. The clinical and histopathological characteristics of 217 PTMCs were evaluated cross-sectionally after surgery, and immunohistochemical staining of p53, epidermal growth factor receptor (EGFR), Ki-67, and cyclooxygenase-2 (COX-2) for 87 isolated specimens was performed. Main outcome: The proportions of extrathyroid extension, lymphatic invasion, and lymph node metastasis cited were 31.9%, 19.2%, and 17.8%, respectively. However, distant metastasis was not noted. Fifty-three (27.1%) patients had multiplicity, and 39 patients (20.0%) had bilateral disease. A primary tumor larger than 5 mm was significantly associated with extrathyroid extension, lymphatic invasion, and lymph node metastasis. The absence of EGFR expression shown by immunohistochemical analysis was closely correlated with extrathyroid extension and lymph node metastasis, while the absence of COX-2 expression was associated with multiplicity and bilaterality. Conclusion: Many patients with PTMC had clinical and histopathological poor prognostic factors. The expression of molecular markers, such as EGFR and COX-2, may have a role in the prognosis of PTMC. When considering all of the prognostic factors, a more tailored management approach appears to be necessary for patients with PTMC.
UR - https://www.scopus.com/pages/publications/35348970378
U2 - 10.1089/thy.2007.0001
DO - 10.1089/thy.2007.0001
M3 - Article
C2 - 17956162
AN - SCOPUS:35348970378
SN - 1050-7256
VL - 17
SP - 883
EP - 888
JO - Thyroid
JF - Thyroid
IS - 9
ER -
