Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Young Woo Jeon; Seugyun Yoon; Gi June Min; Sung Soo Park; Silvia Park; Jae Ho Yoon; Sung Eun Lee; Byung Sik Cho; Ki Seong Eom; Yoo Jin Kim; Hee Je Kim; Seok Lee; Chang Ki Min; Jong Wook Lee; Seok Goo Cho

doi:10.1016/j.clml.2019.03.023

Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Young Woo Jeon, Seugyun Yoon, Gi June Min, Sung Soo Park, Silvia Park, Jae Ho Yoon, Sung Eun Lee, Byung Sik Cho, Ki Seong Eom, Yoo Jin Kim, Hee Je Kim, Seok Lee, Chang Ki Min, Jong Wook Lee, Seok Goo Cho

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This single-institute retrospective study of 89 patients who received reduced-intensity conditioning with the fludarabine/melphalan/total body irradiation regimen, shows favorable transplant outcomes with a relatively low risk of transplant-related toxicities. This combination may be a promising strategy for patients with relapsed or refractory aggressive non-Hodgkin lymphoma.

Original language	English
Pages (from-to)	345-355.e7
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.clml.2019.03.023
State	Published - Jun 2019

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2016R1A2B4007282 ).

Publisher Copyright:
© 2019 The Authors

Keywords

Aggressive lymphoma
Allogeneic hematopoietic stem cell transplantation
FMT-regimen
Graft-versus-lymphoma effect
Reduced-intensity conditioning

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Jeon, Y. W., Yoon, S., Min, G. J., Park, S. S., Park, S., Yoon, J. H., Lee, S. E., Cho, B. S., Eom, K. S., Kim, Y. J., Kim, H. J., Lee, S., Min, C. K., Lee, J. W., & Cho, S. G. (2019). Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Clinical Lymphoma, Myeloma and Leukemia, 19(6), 345-355.e7. https://doi.org/10.1016/j.clml.2019.03.023

Jeon, Young Woo ; Yoon, Seugyun ; Min, Gi June et al. / Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. In: Clinical Lymphoma, Myeloma and Leukemia. 2019 ; Vol. 19, No. 6. pp. 345-355.e7.

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title = "Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation",

abstract = "This single-institute retrospective study of 89 patients who received reduced-intensity conditioning with the fludarabine/melphalan/total body irradiation regimen, shows favorable transplant outcomes with a relatively low risk of transplant-related toxicities. This combination may be a promising strategy for patients with relapsed or refractory aggressive non-Hodgkin lymphoma.",

keywords = "Aggressive lymphoma, Allogeneic hematopoietic stem cell transplantation, FMT-regimen, Graft-versus-lymphoma effect, Reduced-intensity conditioning",

author = "Jeon, \{Young Woo\} and Seugyun Yoon and Min, \{Gi June\} and Park, \{Sung Soo\} and Silvia Park and Yoon, \{Jae Ho\} and Lee, \{Sung Eun\} and Cho, \{Byung Sik\} and Eom, \{Ki Seong\} and Kim, \{Yoo Jin\} and Kim, \{Hee Je\} and Seok Lee and Min, \{Chang Ki\} and Lee, \{Jong Wook\} and Cho, \{Seok Goo\}",

note = "Funding Information: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2016R1A2B4007282 ). Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = jun,

doi = "10.1016/j.clml.2019.03.023",

language = "English",

volume = "19",

pages = "345--355.e7",

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Jeon, YW, Yoon, S, Min, GJ , Park, SS , Park, S , Yoon, JH , Lee, SE , Cho, BS , Eom, KS , Kim, YJ , Kim, HJ, Lee, S, Min, CK, Lee, JW & Cho, SG 2019, 'Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation', Clinical Lymphoma, Myeloma and Leukemia, vol. 19, no. 6, pp. 345-355.e7. https://doi.org/10.1016/j.clml.2019.03.023

Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. / Jeon, Young Woo; Yoon, Seugyun; Min, Gi June et al.
In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 19, No. 6, 06.2019, p. 345-355.e7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

AU - Jeon, Young Woo

AU - Yoon, Seugyun

AU - Min, Gi June

AU - Park, Sung Soo

AU - Park, Silvia

AU - Yoon, Jae Ho

AU - Lee, Sung Eun

AU - Cho, Byung Sik

AU - Eom, Ki Seong

AU - Kim, Yoo Jin

AU - Kim, Hee Je

AU - Lee, Seok

AU - Min, Chang Ki

AU - Lee, Jong Wook

AU - Cho, Seok Goo

N1 - Funding Information: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2016R1A2B4007282 ). Publisher Copyright: © 2019 The Authors

PY - 2019/6

Y1 - 2019/6

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AB - This single-institute retrospective study of 89 patients who received reduced-intensity conditioning with the fludarabine/melphalan/total body irradiation regimen, shows favorable transplant outcomes with a relatively low risk of transplant-related toxicities. This combination may be a promising strategy for patients with relapsed or refractory aggressive non-Hodgkin lymphoma.

KW - Aggressive lymphoma

KW - Allogeneic hematopoietic stem cell transplantation

KW - FMT-regimen

KW - Graft-versus-lymphoma effect

KW - Reduced-intensity conditioning

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JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

IS - 6

ER -

Jeon YW, Yoon S, Min GJ , Park SS , Park S , Yoon JH et al. Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Clinical Lymphoma, Myeloma and Leukemia. 2019 Jun;19(6):345-355.e7. doi: 10.1016/j.clml.2019.03.023

Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Abstract

Bibliographical note

Keywords

UN SDGs

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