Abstract
Transplantation research has focused on cytotoxic T-cell and plasma cell/ B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 860-866 |
| Number of pages | 7 |
| Journal | Korean Journal of Internal Medicine |
| Volume | 33 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2018 |
Bibliographical note
Publisher Copyright:© 2018 The Korean Association of Internal Medicine.
Keywords
- Allograft rejection
- Chronic allograft dysfunction
- Kidney transplantation
- Mammalian target of rapamycin
- Th17 cells
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