Clinical study of 28 cases of extramammary Paget's disease

Background: Extramammary Paget's disease (EMPD) is a rare skin neoplasm most commonly involving apocrine-bearing regions including the perineum, perianal, scrotal and vulvar areas. Objective: The aim of this study was to identify in detail the clinical findings of EMPD in Korea. Method: A total of 28 patients confirmed with EMPD from July 1995 to July 2004 were included. We reviewed clinical records of the past history, clinical characteristics, and associated internal malignancy. Results: In EMPD, the patients' age was from 45 to 86 years (median 64.6 years) and incidence was more frequent in men than women (23:5, male:female). The most common predilection site was the penoscrotal area in men and the vulva in women. Two of 28 patients with EMPD had an underlying malignancy. Two of 28 patients treated with wide excision had local recurrence during the follow-up period. Conclusion: EMPD in Korea may be characterized by male predominance and penoscrotal location. The incidence of concomitant malignancy may be lower than that in Caucasians. However, investigation for internal malignancy and regular follow-up for recurrence is still warranted.