Abstract
Heme oxygenase-1 (HO-1), a stress-response protein, is highly induced in various carcinomas. It is implicated in carcinogenesis and tumor progression. High HO-1 expression is associated with better prognosis of patients with colorectal and gastric cancers. Induction or inhibition of HO-1 can mediate chemo-sensitivity, therefore it might be a therapeutic target to develop anticancer agents. To define the clinicopathological and prognostic significance of HO-1 expression in small-intestinal adenocarcinomas (SIACs), immunohistochemical microarray analysis of HO-1 expression was performed for 191 surgically resected SIAC cases and results were compared with various clinicopathologic variables, including survival. HO-1 was highly expressed in 127 (66.5%) cases. Patients with high HO-1 expression were associated with younger age (P = 0.048), lower pT category (P = 0.017), and less pancreatic invasion (P = 0.047). Patients with high HO-1 expression tended to have longer overall survival (median, 38.5 months) than those with low HO-1 expression (24.5 months), although the difference in overall survival was not statistically significant (P = 0.677). In summary, high HO-1 expression is frequently observed in SIACs. It is related to favorable clinicopathologic parameters, including younger age, lower T category, and less pancreatic invasion. Therefore, HO-1 may serve as a prognostic marker and a new target to modulate chemotherapeutic effects in patients with SIACs.
| Original language | English |
|---|---|
| Pages (from-to) | 294-300 |
| Number of pages | 7 |
| Journal | Pathology International |
| Volume | 68 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2018 |
Bibliographical note
Funding Information:This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2017R1D1A1B03031817) and a grant (2016-0004) from the Gangneung Asan Hospital Biomedical Research Center Promotion Fund. We would like to thank members of the Korean Small Intestinal Cancer Study Group for providing samples and data for this study: Dr. Hee-Kyung Chang, Kosin University College of Medicine, Pusan; Dr. Kee-Taek Jang, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Dr. Ghil Suk Yoon, Kyungpook National University School of Medicine, Dague; Dr. Joon Mee Kim, Inha University College of Medicine, Incheon; Dr. Hyun-Jung Kim, Inje University Sanggye Paik Hospital, Seoul; Dr. Gwang Il Kim, CHA Bundang Medical Center, CHA University, Seongnam; Dr. Su-Jin Shin, Hanyang University College of Medicine, Seoul; Dr. Jinwon Seo, Hallym University Sacred Heart Hospital, Anyang; Dr. Eun Kyoung Kwak, Fatima Hospital, Daegu; Dr. Eun Sun Jung, The Catholic University of Korea College of Medicine, Seoul; Dr. Young-Ha Oh, Hanyang University College of Medicine, Guri; Dr. Jae Bok Park, Catholic University of Daegu, Daegu; Dr. Soo Jin Jung, Inje University College of Medicine, Busan; Dr. Gyeong Hoon Kang, Seoul National University College of Medicine, Seoul; Dr. Heae Sung Park, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul; and Dr. Ji Shin Lee, Chonnam National University Medical School, Gwangju, Korea.
Publisher Copyright:
© 2018 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd
Keywords
- heme oxygenase-1
- immunohistochemistry
- small intestine
- survival
