Abstract
The control of mammalian mRNA turnover and translation has been linked almost exclusively to specific ciselements within the 5′- and 3′-untranslated regions (UTRs) of the mature mRNA. However, instances of regulated turnover and translation via cis-elements within the coding region (CR) of mRNAs are accumulating. Here, we describe the regulation of post-transcriptional fate through trans-binding factors (RNA-binding proteins and microRNAs) that function via CR sequences. We discuss how the CR enriches the post-transcriptional control of gene expression, and predict that new high-throughput technologies will enable a more mainstream study of CR-governed gene regulation.
| Original language | English |
|---|---|
| Journal | RNA Biology |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2011 |
Bibliographical note
Funding Information:This work was funded by the Intramural Research Program of the National Institute on Aging-Intramural Research Program, National Institutes of Health.
Keywords
- Coding region
- Mammalian post-transcriptional gene expression
- Polysomes
- RNA-binding proteins
- Translation
- mRNA turnover
- microRNAs
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