Comparative genome hybridization array analysis for sporadic Parkinson's disease

Joong Seok Kim; Ji Yeon Yoo; Kwang Soo Lee; Hye Sung Kim; Jin Soo Choi; Hyoung Kyun Rha; Sung Vin Yim; Kweon Haeng Lee

doi:10.1080/00207450802174522

Comparative genome hybridization array analysis for sporadic Parkinson's disease

Joong Seok Kim
, Ji Yeon Yoo
, Kwang Soo Lee
, Hye Sung Kim
, Jin Soo Choi
, Hyoung Kyun Rha
, Sung Vin Yim
, Kweon Haeng Lee

The Catholic University of Korea
Catholic Univ. of Korea Coll. Med.
Kyung Hee University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Parkinson disease (PD) is a common neurodegenerative disorder, characterized by the loss of midbrain dopamine neurons and Lewy body inclusions. We investigated array CGH to analyze gain or loss of genetic material from 30 patients with PD. We identified the frequent copy number variations in PD; gains in 1p21.1, 4p15.31, 5p15.33, 6q24.1, 7q35, 8q24.3, 10q26.3, 11p15.5-15.4, 12q21.2, 16p13.3, 18q12.3 and 22q13.31, and losses in 1p36.33, and 5q13.2. These findings enable a better description of genetic variations in PD, and could provide a foundation for understanding the critical regions of the genome that may be involved in the development of PD.

Original language	English
Pages (from-to)	1331-1345
Number of pages	15
Journal	International Journal of Neuroscience
Volume	118
Issue number	9
DOIs	https://doi.org/10.1080/00207450802174522
State	Published - Sep 2008

Bibliographical note

Funding Information:
This study was supported by a grant (00-PJ3-PG6-GN02–0002) from the Korean Health 21 R&D Project, the Ministry of Health and Welfare, Republic of Korea.

Keywords

Array CGH
Copy number variations (CNVs)
Gene alteration
Genomic aberration
Parkinson disease
Real time PCR

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10.1080/00207450802174522

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title = "Comparative genome hybridization array analysis for sporadic Parkinson's disease",

abstract = "Parkinson disease (PD) is a common neurodegenerative disorder, characterized by the loss of midbrain dopamine neurons and Lewy body inclusions. We investigated array CGH to analyze gain or loss of genetic material from 30 patients with PD. We identified the frequent copy number variations in PD; gains in 1p21.1, 4p15.31, 5p15.33, 6q24.1, 7q35, 8q24.3, 10q26.3, 11p15.5-15.4, 12q21.2, 16p13.3, 18q12.3 and 22q13.31, and losses in 1p36.33, and 5q13.2. These findings enable a better description of genetic variations in PD, and could provide a foundation for understanding the critical regions of the genome that may be involved in the development of PD.",

keywords = "Array CGH, Copy number variations (CNVs), Gene alteration, Genomic aberration, Parkinson disease, Real time PCR",

author = "Kim, \{Joong Seok\} and Yoo, \{Ji Yeon\} and Lee, \{Kwang Soo\} and Kim, \{Hye Sung\} and Choi, \{Jin Soo\} and Rha, \{Hyoung Kyun\} and Yim, \{Sung Vin\} and Lee, \{Kweon Haeng\}",

note = "Funding Information: This study was supported by a grant (00-PJ3-PG6-GN02–0002) from the Korean Health 21 R\&D Project, the Ministry of Health and Welfare, Republic of Korea.",

year = "2008",

month = sep,

doi = "10.1080/00207450802174522",

language = "English",

volume = "118",

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T1 - Comparative genome hybridization array analysis for sporadic Parkinson's disease

AU - Kim, Joong Seok

AU - Yoo, Ji Yeon

AU - Lee, Kwang Soo

AU - Kim, Hye Sung

AU - Choi, Jin Soo

AU - Rha, Hyoung Kyun

AU - Yim, Sung Vin

AU - Lee, Kweon Haeng

N1 - Funding Information: This study was supported by a grant (00-PJ3-PG6-GN02–0002) from the Korean Health 21 R&D Project, the Ministry of Health and Welfare, Republic of Korea.

PY - 2008/9

Y1 - 2008/9

N2 - Parkinson disease (PD) is a common neurodegenerative disorder, characterized by the loss of midbrain dopamine neurons and Lewy body inclusions. We investigated array CGH to analyze gain or loss of genetic material from 30 patients with PD. We identified the frequent copy number variations in PD; gains in 1p21.1, 4p15.31, 5p15.33, 6q24.1, 7q35, 8q24.3, 10q26.3, 11p15.5-15.4, 12q21.2, 16p13.3, 18q12.3 and 22q13.31, and losses in 1p36.33, and 5q13.2. These findings enable a better description of genetic variations in PD, and could provide a foundation for understanding the critical regions of the genome that may be involved in the development of PD.

AB - Parkinson disease (PD) is a common neurodegenerative disorder, characterized by the loss of midbrain dopamine neurons and Lewy body inclusions. We investigated array CGH to analyze gain or loss of genetic material from 30 patients with PD. We identified the frequent copy number variations in PD; gains in 1p21.1, 4p15.31, 5p15.33, 6q24.1, 7q35, 8q24.3, 10q26.3, 11p15.5-15.4, 12q21.2, 16p13.3, 18q12.3 and 22q13.31, and losses in 1p36.33, and 5q13.2. These findings enable a better description of genetic variations in PD, and could provide a foundation for understanding the critical regions of the genome that may be involved in the development of PD.

KW - Array CGH

KW - Copy number variations (CNVs)

KW - Gene alteration

KW - Genomic aberration

KW - Parkinson disease

KW - Real time PCR

UR - https://www.scopus.com/pages/publications/49549110961

U2 - 10.1080/00207450802174522

DO - 10.1080/00207450802174522

M3 - Article

C2 - 18698514

AN - SCOPUS:49549110961

SN - 0020-7454

VL - 118

SP - 1331

EP - 1345

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 9

ER -

Comparative genome hybridization array analysis for sporadic Parkinson's disease

Abstract

Bibliographical note

Keywords

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