Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma

Masaki Kaibori; Masanori Kon; Tomoki Kitawaki; Takayuki Kawaura; Kiyoshi Hasegawa; Norihiro Kokudo; Shunichi Ariizumi; Toru Beppu; Hiroyuki Ishizu; Shoji Kubo; Toshiya Kamiyama; Hiroyuki Takamura; Tsuyoshi Kobayashi; Dong Sik Kim; Hee Jung Wang; Jong Man Kim; Dai Hoon Han; Sang Jae Park; Koo Jeong Kang; Shin Hwang; Younghoon Roh; Young Kyung You; Jae Won Joh; Masakazu Yamamoto

doi:10.1002/jhbp.502

Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma

Masaki Kaibori, Masanori Kon, Tomoki Kitawaki, Takayuki Kawaura, Kiyoshi Hasegawa, Norihiro Kokudo, Shunichi Ariizumi, Toru Beppu, Hiroyuki Ishizu, Shoji Kubo, Toshiya Kamiyama, Hiroyuki Takamura, Tsuyoshi Kobayashi, Dong Sik Kim, Hee Jung Wang, Jong Man Kim, Dai Hoon Han, Sang Jae Park, Koo Jeong Kang, Shin HwangYounghoon Roh, Young Kyung You, Jae Won Joh, Masakazu Yamamoto

Department of Surgery

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Background: The aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). Methods: To control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0 cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. Results: Overall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28–2.19, P < 0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. Conclusions: Anatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0 cm in diameter.

Original language	English
Pages (from-to)	616-626
Number of pages	11
Journal	Journal of Hepato-Biliary-Pancreatic Sciences
Volume	24
Issue number	11
DOIs	https://doi.org/10.1002/jhbp.502
State	Published - Nov 2017

Bibliographical note

Publisher Copyright:
© 2017 Japanese Society of Hepato-Biliary-Pancreatic Surgery

Keywords

Anatomic resection
Hepatocellular carcinoma
Non-anatomic resection
Overall survival

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10.1002/jhbp.502

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Kaibori, M., Kon, M., Kitawaki, T., Kawaura, T., Hasegawa, K., Kokudo, N., Ariizumi, S., Beppu, T., Ishizu, H., Kubo, S., Kamiyama, T., Takamura, H., Kobayashi, T., Kim, D. S., Wang, H. J., Kim, J. M., Han, D. H., Park, S. J., Kang, K. J., ... Yamamoto, M. (2017). Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma. Journal of Hepato-Biliary-Pancreatic Sciences, 24(11), 616-626. https://doi.org/10.1002/jhbp.502

@article{93696bc797b047899299ab563081a101,

title = "Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma",

abstract = "Background: The aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). Methods: To control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0 cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. Results: Overall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28–2.19, P < 0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. Conclusions: Anatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0 cm in diameter.",

keywords = "Anatomic resection, Hepatocellular carcinoma, Non-anatomic resection, Overall survival",

author = "Masaki Kaibori and Masanori Kon and Tomoki Kitawaki and Takayuki Kawaura and Kiyoshi Hasegawa and Norihiro Kokudo and Shunichi Ariizumi and Toru Beppu and Hiroyuki Ishizu and Shoji Kubo and Toshiya Kamiyama and Hiroyuki Takamura and Tsuyoshi Kobayashi and Kim, {Dong Sik} and Wang, {Hee Jung} and Kim, {Jong Man} and Han, {Dai Hoon} and Park, {Sang Jae} and Kang, {Koo Jeong} and Shin Hwang and Younghoon Roh and You, {Young Kyung} and Joh, {Jae Won} and Masakazu Yamamoto",

note = "Publisher Copyright: {\textcopyright} 2017 Japanese Society of Hepato-Biliary-Pancreatic Surgery",

year = "2017",

month = nov,

doi = "10.1002/jhbp.502",

language = "English",

volume = "24",

pages = "616--626",

journal = "Journal of Hepato-Biliary-Pancreatic Sciences",

issn = "1868-6974",

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Kaibori, M, Kon, M, Kitawaki, T, Kawaura, T, Hasegawa, K, Kokudo, N, Ariizumi, S, Beppu, T, Ishizu, H, Kubo, S, Kamiyama, T, Takamura, H, Kobayashi, T, Kim, DS, Wang, HJ, Kim, JM, Han, DH, Park, SJ, Kang, KJ, Hwang, S, Roh, Y, You, YK, Joh, JW & Yamamoto, M 2017, 'Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 24, no. 11, pp. 616-626. https://doi.org/10.1002/jhbp.502

TY - JOUR

T1 - Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma

AU - Kaibori, Masaki

AU - Kon, Masanori

AU - Kitawaki, Tomoki

AU - Kawaura, Takayuki

AU - Hasegawa, Kiyoshi

AU - Kokudo, Norihiro

AU - Ariizumi, Shunichi

AU - Beppu, Toru

AU - Ishizu, Hiroyuki

AU - Kubo, Shoji

AU - Kamiyama, Toshiya

AU - Takamura, Hiroyuki

AU - Kobayashi, Tsuyoshi

AU - Kim, Dong Sik

AU - Wang, Hee Jung

AU - Kim, Jong Man

AU - Han, Dai Hoon

AU - Park, Sang Jae

AU - Kang, Koo Jeong

AU - Hwang, Shin

AU - Roh, Younghoon

AU - You, Young Kyung

AU - Joh, Jae Won

AU - Yamamoto, Masakazu

PY - 2017/11

Y1 - 2017/11

N2 - Background: The aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). Methods: To control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0 cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. Results: Overall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28–2.19, P < 0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. Conclusions: Anatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0 cm in diameter.

AB - Background: The aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). Methods: To control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0 cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. Results: Overall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28–2.19, P < 0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. Conclusions: Anatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0 cm in diameter.

KW - Anatomic resection

KW - Hepatocellular carcinoma

KW - Non-anatomic resection

KW - Overall survival

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U2 - 10.1002/jhbp.502

DO - 10.1002/jhbp.502

M3 - Article

C2 - 28887834

AN - SCOPUS:85032722450

SN - 1868-6974

VL - 24

SP - 616

EP - 626

JO - Journal of Hepato-Biliary-Pancreatic Sciences

JF - Journal of Hepato-Biliary-Pancreatic Sciences

IS - 11

ER -

Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma

Abstract

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Keywords

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