Comparison of EASYPREP® and SurePath® in thyroid fine-needle aspiration

Yosep Chong, Ki Hyun Baek, Jee Young Kim, Tae Jung Kim, Eun Jung Lee, Chang Suk Kang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background While fine-needle aspiration cytology (FNAC) using conventional smear has been widely accepted as the primary diagnostic tool for thyroid lesions, liquid-based preparations (LBPs) are increasingly replacing it. A new automated LBP method, EASYPREP® (EP), was recently introduced and has shown relevant diagnostic efficacy in gynecologic samples. We compared the diagnostic utility of EP and SurePath® (SP), a more widely established LBP method, in thyroid FNAC. Methods Under the ultrasonographic guidance, 253 thyroid FNAC samples were collected by sample-splitting manner. Three pathologists made cytologic diagnoses of EP and SP according to the Bethesda system independently and compared the cytomorphologic parameters. Cytohistologic correlation was performed in 30 resected cases. Results Fifteen (5.9%) and 21 (8.3%) samples were unsatisfactory in SP and EP, respectively, owing to the unequal sample-splitting. Cytologic diagnoses of SP and EP were consistent in 228 cases (90.1%), and inconsistent in remainder mostly owing to the unequal distribution of pathognomic cells. While cytomorphologic parameters were not significantly different between two methods, EP showed less three-dimensional configuration in benign lesions. Cytohistologic correlation showed no significant differences in sensitivity (100% vs. 95.5%) and specificity (100% vs. 100%) between SP and EP. Labor time for processing 48 cases was 42% shorter with EP than with SP (28 min vs. 48 min). Conclusions The diagnostic utility of EP in thyroid FNAC was comparable to that of SP. EP allowed better visibility owing to better fragmentation of follicular clusters. The automated system of EP has the advantages of a shorter labor time for batch processing.

Original languageEnglish
Pages (from-to)283-290
Number of pages8
JournalDiagnostic Cytopathology
Volume44
Issue number4
DOIs
StatePublished - 1 Apr 2016

Bibliographical note

Funding Information:
Ministry of Health and Welfare, Republic of Korea.

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

Keywords

  • EASYPREP
  • cytological techniques
  • fine-needle aspiration biopsy
  • thyroid gland

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