Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma

Jin H.o. Song; Bae Kwon Jeong; Hoon Sik Choi; Hojin Jeong; Myoung H.ee Kang; Jung H.un Kang; Jin P.yeong Kim; Jung J.e. Park; Seung H.oon Woo; Hong S.eok Jang; Byung O.ck Choi; Ki M.un Kang

Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma

Jin H.o. Song, Bae Kwon Jeong, Hoon Sik Choi, Hojin Jeong, Myoung H.ee Kang, Jung H.un Kang, Jin P.yeong Kim, Jung J.e. Park, Seung H.oon Woo, Hong S.eok Jang, Byung O.ck Choi, Ki M.un Kang

Department of Radiation Oncology

Gyeongsang National University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

BACKGROUND: We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC).

PATIENTS AND METHODS: We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT.

RESULTS: There were 13 locoregional recurrences as initial failure sites. Eight recurrences were local, three were regional, and two were both local and regional. The recurrence pattern did not differ between the 3D-RT- and IMRT-treated groups, while toxicities were reduced in the IMRT-treated group. All recurrences were within the high-risk planning target volume except for one case in IMRT.

CONCLUSION: IMRT did not increase the risk of locoregional recurrence neither did it change the pattern of failure in patients with stage III-IV locally advanced HNSCC, although it did reduce toxicities.

Original language	English
Pages (from-to)	6833-6840
Number of pages	8
Journal	Anticancer Research
Volume	35
Issue number	12
State	Published - 1 Dec 2015

Bibliographical note

Publisher Copyright:
Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Keywords

Head and neck cancer
intensity-modulated radiotherapy
patterns of failure
radiotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Song, J. H. O., Jeong, B. K., Choi, H. S., Jeong, H., Kang, M. H. E., Kang, J. H. U., Kim, J. P. Y., Park, J. J. E., Woo, S. H. O., Jang, H. S. E., Choi, B. O. C., & Kang, K. M. U. (2015). Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma. Anticancer Research, 35(12), 6833-6840.

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title = "Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma",

abstract = "BACKGROUND: We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC).PATIENTS AND METHODS: We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT.RESULTS: There were 13 locoregional recurrences as initial failure sites. Eight recurrences were local, three were regional, and two were both local and regional. The recurrence pattern did not differ between the 3D-RT- and IMRT-treated groups, while toxicities were reduced in the IMRT-treated group. All recurrences were within the high-risk planning target volume except for one case in IMRT.CONCLUSION: IMRT did not increase the risk of locoregional recurrence neither did it change the pattern of failure in patients with stage III-IV locally advanced HNSCC, although it did reduce toxicities.",

keywords = "Head and neck cancer, intensity-modulated radiotherapy, patterns of failure, radiotherapy",

author = "Song, {Jin H.o.} and Jeong, {Bae Kwon} and Choi, {Hoon Sik} and Hojin Jeong and Kang, {Myoung H.ee} and Kang, {Jung H.un} and Kim, {Jin P.yeong} and Park, {Jung J.e.} and Woo, {Seung H.oon} and Jang, {Hong S.eok} and Choi, {Byung O.ck} and Kang, {Ki M.un}",

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AU - Song, Jin H.o.

AU - Jeong, Bae Kwon

AU - Choi, Hoon Sik

AU - Jeong, Hojin

AU - Kang, Myoung H.ee

AU - Kang, Jung H.un

AU - Kim, Jin P.yeong

AU - Park, Jung J.e.

AU - Woo, Seung H.oon

AU - Jang, Hong S.eok

AU - Choi, Byung O.ck

AU - Kang, Ki M.un

PY - 2015/12/1

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N2 - BACKGROUND: We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC).PATIENTS AND METHODS: We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT.RESULTS: There were 13 locoregional recurrences as initial failure sites. Eight recurrences were local, three were regional, and two were both local and regional. The recurrence pattern did not differ between the 3D-RT- and IMRT-treated groups, while toxicities were reduced in the IMRT-treated group. All recurrences were within the high-risk planning target volume except for one case in IMRT.CONCLUSION: IMRT did not increase the risk of locoregional recurrence neither did it change the pattern of failure in patients with stage III-IV locally advanced HNSCC, although it did reduce toxicities.

AB - BACKGROUND: We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC).PATIENTS AND METHODS: We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT.RESULTS: There were 13 locoregional recurrences as initial failure sites. Eight recurrences were local, three were regional, and two were both local and regional. The recurrence pattern did not differ between the 3D-RT- and IMRT-treated groups, while toxicities were reduced in the IMRT-treated group. All recurrences were within the high-risk planning target volume except for one case in IMRT.CONCLUSION: IMRT did not increase the risk of locoregional recurrence neither did it change the pattern of failure in patients with stage III-IV locally advanced HNSCC, although it did reduce toxicities.

KW - Head and neck cancer

KW - intensity-modulated radiotherapy

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Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

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