TY - JOUR
T1 - Comparison of the effects of intravenous propofol and inhalational desflurane on the quality of early recovery after hand-assisted laparoscopic donor nephrectomy
T2 - A prospective, randomised controlled trial
AU - Park, Jaesik
AU - Kim, Minhee
AU - Park, Yong Hyun
AU - Shim, Jung Woo
AU - Lee, Hyung Mook
AU - Kim, Yong Suk
AU - Moon, Young Eun
AU - Hong, Sang Hyun
AU - Chae, Min Suk
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2020/12/15
Y1 - 2020/12/15
N2 - Objectives We compared early recovery outcomes between living kidney donors who received total intravenous (IV) propofol versus inhalational desflurane during hand-assisted laparoscopic nephrectomy. Design A single-centre, prospective randomised controlled trial. Setting University hospital. Participants Study participants were enrolled between October 2019 and February 2020. A total of 80 living donors were randomly assigned to an intravenous propofol group (n=40) or a desflurane group (n=40). Intervention Propofol group received intravenous propofol and desflurane group received desflurane, as a maintenance anaesthetic. Primary and secondary outcome measures The quality of postoperative functional recovery was primarily assessed using the Korean version of the Quality of Recovery-40 (QoR-40K) questionnaire on postoperative day 1. Secondarily, ambulation, pain score, rescue analgesics, complications and total hospital stay were assessed postoperatively. Results Our study population included 35 males and 45 females. The mean age was 46±13 years. The global QoR-40K score (161 (154-173) vs 152 (136-161) points, respectively, p=0.001) and all five subdimension scores (physical comfort, 49 (45-53) vs 45 (42-48) points, respectively, p=0.003; emotional state, 39 (37-41) vs 37 (33-41) points, respectively, p=0.005; psychological support, 30 (26-34) vs 28 (26-32) points, respectively, p=0.04; physical independence, 16 (11-18) vs 12 (8-14) points, respectively, p=0.004; and pain, 31 (28-33) vs 29 (25-31) points, respectively, p=0.021) were significantly higher in the intravenous propofol group than the desflurane group. The early ambulation success rate and numbers of early and total steps were higher, but the incidence of nausea/vomiting was lower, in the intravenous propofol group than the desflurane group. The total hospital stay after surgery was shorter in the intravenous propofol group than the desflurane group. Conclusions Intravenous propofol may enhance the quality of postoperative recovery in comparison to desflurane in living kidney donors. Trial registration number KCT0004365.
AB - Objectives We compared early recovery outcomes between living kidney donors who received total intravenous (IV) propofol versus inhalational desflurane during hand-assisted laparoscopic nephrectomy. Design A single-centre, prospective randomised controlled trial. Setting University hospital. Participants Study participants were enrolled between October 2019 and February 2020. A total of 80 living donors were randomly assigned to an intravenous propofol group (n=40) or a desflurane group (n=40). Intervention Propofol group received intravenous propofol and desflurane group received desflurane, as a maintenance anaesthetic. Primary and secondary outcome measures The quality of postoperative functional recovery was primarily assessed using the Korean version of the Quality of Recovery-40 (QoR-40K) questionnaire on postoperative day 1. Secondarily, ambulation, pain score, rescue analgesics, complications and total hospital stay were assessed postoperatively. Results Our study population included 35 males and 45 females. The mean age was 46±13 years. The global QoR-40K score (161 (154-173) vs 152 (136-161) points, respectively, p=0.001) and all five subdimension scores (physical comfort, 49 (45-53) vs 45 (42-48) points, respectively, p=0.003; emotional state, 39 (37-41) vs 37 (33-41) points, respectively, p=0.005; psychological support, 30 (26-34) vs 28 (26-32) points, respectively, p=0.04; physical independence, 16 (11-18) vs 12 (8-14) points, respectively, p=0.004; and pain, 31 (28-33) vs 29 (25-31) points, respectively, p=0.021) were significantly higher in the intravenous propofol group than the desflurane group. The early ambulation success rate and numbers of early and total steps were higher, but the incidence of nausea/vomiting was lower, in the intravenous propofol group than the desflurane group. The total hospital stay after surgery was shorter in the intravenous propofol group than the desflurane group. Conclusions Intravenous propofol may enhance the quality of postoperative recovery in comparison to desflurane in living kidney donors. Trial registration number KCT0004365.
KW - adult anaesthesia
KW - adult urology
KW - anaesthesia in urology
KW - quality in health care
KW - transplant surgery
UR - http://www.scopus.com/inward/record.url?scp=85097868723&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2020-039881
DO - 10.1136/bmjopen-2020-039881
M3 - Article
C2 - 33323432
AN - SCOPUS:85097868723
SN - 2044-6055
VL - 10
JO - BMJ Open
JF - BMJ Open
IS - 12
M1 - e039881
ER -