Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway

Hong Seok Jang; Kyu Eun Ryu; Woong Shick Ahn; Heung Jae Chun; Hyung Dal Park; Ki Dong Park; Young Ha Kim

doi:10.1016/j.colsurfb.2006.03.024

Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway

Hong Seok Jang
, Kyu Eun Ryu
, Woong Shick Ahn
, Heung Jae Chun
, Hyung Dal Park
, Ki Dong Park
, Young Ha Kim

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO₃A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO₃A chains in water phase. As continuation study, anti-complement effects of PEG-SO₃/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO₃/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO₃/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO₃/OA samples markedly decreased SC5b-9 levels in plasma.

Original language	English
Pages (from-to)	141-146
Number of pages	6
Journal	Colloids and Surfaces B: Biointerfaces
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/j.colsurfb.2006.03.024
State	Published - 1 Jul 2006

Bibliographical note

Funding Information:
This study was supported by a grant (10012112), Components and Materials Technology Development Program from the Ministry of Commerce, Industry and Energy, Republic of Korea.

Keywords

Acrylate
Alternative pathway
Biomaterials
Copolymerization
Poly(ethylene glycol)
Sulfonation complement activation

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10.1016/j.colsurfb.2006.03.024

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title = "Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway",

abstract = "Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO3A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO3A chains in water phase. As continuation study, anti-complement effects of PEG-SO3/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO3/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO3/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO3/OA samples markedly decreased SC5b-9 levels in plasma.",

keywords = "Acrylate, Alternative pathway, Biomaterials, Copolymerization, Poly(ethylene glycol), Sulfonation complement activation",

author = "Jang, \{Hong Seok\} and Ryu, \{Kyu Eun\} and Ahn, \{Woong Shick\} and Chun, \{Heung Jae\} and \{Dal Park\}, Hyung and Park, \{Ki Dong\} and Kim, \{Young Ha\}",

note = "Funding Information: This study was supported by a grant (10012112), Components and Materials Technology Development Program from the Ministry of Commerce, Industry and Energy, Republic of Korea.",

year = "2006",

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doi = "10.1016/j.colsurfb.2006.03.024",

language = "English",

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T1 - Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway

AU - Jang, Hong Seok

AU - Ryu, Kyu Eun

AU - Ahn, Woong Shick

AU - Chun, Heung Jae

AU - Dal Park, Hyung

AU - Park, Ki Dong

AU - Kim, Young Ha

N1 - Funding Information: This study was supported by a grant (10012112), Components and Materials Technology Development Program from the Ministry of Commerce, Industry and Energy, Republic of Korea.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO3A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO3A chains in water phase. As continuation study, anti-complement effects of PEG-SO3/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO3/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO3/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO3/OA samples markedly decreased SC5b-9 levels in plasma.

AB - Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO3A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO3A chains in water phase. As continuation study, anti-complement effects of PEG-SO3/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO3/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO3/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO3/OA samples markedly decreased SC5b-9 levels in plasma.

KW - Acrylate

KW - Alternative pathway

KW - Biomaterials

KW - Copolymerization

KW - Poly(ethylene glycol)

KW - Sulfonation complement activation

UR - https://www.scopus.com/pages/publications/33745335810

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DO - 10.1016/j.colsurfb.2006.03.024

M3 - Article

C2 - 16797170

AN - SCOPUS:33745335810

SN - 0927-7765

VL - 50

SP - 141

EP - 146

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 2

ER -

Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway

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